OPRM1, opioid receptor mu 1, 4988

N. diseases: 370; N. variants: 42
Disease: Major Depressive Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 Biomarker disease BEFREE Modulation of the opioid system has re-emerged as a potential therapeutic avenue for treating depression, with efficacy of a fixed-dose combination of buprenorphine (BUP), a partial μ-opioid receptor (MOR) agonist and κ-opioid receptor (KOR) antagonist, and samidorphan (SAM), a potent MOR antagonist, as an adjuvant treatment in patients with major depressive disorder (MDD). 30553825 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 Biomarker disease BEFREE The aim of the present study was to examine the relation between β-Endorphin (β-EP), Endomorphin-2, and their mu-opioid receptor (MOR) as well as interleukin (IL)-6 and IL-10, an anti-inflammatory cytokine, in MDD patients. 30677547 2019
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 Biomarker disease BEFREE Our results may implicate the MOR in neuropsychiatric disorders characterized by altered social motivation, such as major depression and autism spectrum disorder. 29331800 2018
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 Biomarker disease BEFREE Effect of OPRM1 and stressful life events on symptoms of major depression in African American adolescents. 24766998 2014
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 GeneticVariation disease BEFREE In this study, we examined whether the OPRM1 gene, which has been implicated in antidepressant treatment response in major depressive disorder, also has an effect in GAD. 23658070 2013
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.060 GeneticVariation disease BEFREE Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder. 20194481 2010