|
Colorectal Carcinoma
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Short stature
|
0.100 |
CausalMutation
|
phenotype |
CLINVAR |
|
|
|
|
Solid Neoplasm
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Identification of a gene encoding a human oxysterol-binding protein-homologue: a potential general molecular marker for blood dissemination of solid tumors.
|
10446991 |
1999 |
|
Solid Neoplasm
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
We also analysed the presence of mRNA for HLM, a human oxysterol-binding protein homologue recently described as a potential marker for blood dissemination of solid tumors.
|
11295104 |
2001 |
|
Arteriosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to assess the role of macrophage OSBP-related protein 1L (ORP1L) in the development of atherosclerosis.
|
17478758 |
2007 |
|
Atherosclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to assess the role of macrophage OSBP-related protein 1L (ORP1L) in the development of atherosclerosis.
|
17478758 |
2007 |
|
Atherosclerotic lesion
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of human OSBP-related protein 1L in macrophages enhances atherosclerotic lesion development in LDL receptor-deficient mice.
|
17478758 |
2007 |
|
Metabolic Syndrome X
|
0.010 |
Biomarker
|
disease |
BEFREE |
The oxysterol-binding protein-like protein 11 (OSBPL11) that belongs to the OSBP family of intracellular receptors was one of the genes found to be significantly overexpressed in the MetS group.
|
19325544 |
2009 |
|
Hyperlipidemia, Familial Combined
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Analysis of variants in three genes encoding oxysterol-binding protein (OSBP) homologues (OSBPL2, OSBPL9, OSBPL10) in Finnish families with familial low high-density lipoprotein (HDL) levels (N = 426) or familial combined hyperlipidemia (N = 684) revealed suggestive linkage of OSBPL10 single-nucleotide polymorphisms (SNPs) with extreme end high triglyceride (TG; >90th percentile) trait.
|
19554302 |
2009 |
|
Pancreatic carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of oxysterol binding protein-related protein (ORP) 5 is related to invasion and a poor prognosis in pancreatic cancer patients.
|
20128820 |
2010 |
|
Malignant neoplasm of pancreas
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of oxysterol binding protein-related protein (ORP) 5 is related to invasion and a poor prognosis in pancreatic cancer patients.
|
20128820 |
2010 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression of oxysterol binding protein-related protein (ORP) 5 is related to invasion and a poor prognosis in pancreatic cancer patients.
|
20128820 |
2010 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
|
21763455 |
2012 |
|
Cholangiocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
|
21763455 |
2012 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Expression of oxysterol binding protein isoforms in opisthorchiasis-associated cholangiocarcinoma: a potential molecular marker for tumor metastasis.
|
21763455 |
2012 |
|
AMYOTROPHIC LATERAL SCLEROSIS 8 (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hence, we propose that the ALS8 mutation impairs the interaction of Vap with Osbp, resulting in hypomorphic defects that might contribute to the pathology of ALS8.
|
24271015 |
2014 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
OSBP, a 7-amino-acid peptide with high affinity for human ovarian cancer HO8910 cells, was conjugated to the cell-penetrating peptide (TAT) to form a tumor-selective peptide (TAT-OSBP), which was further conjugated with EGFP or MKK6(E).
|
26495757 |
2015 |
|
Amyotrophic Lateral Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oxysterol-binding protein ORP3 rescues the Amyotrophic Lateral Sclerosis-linked mutant VAPB phenotype.
|
26812496 |
2016 |
|
Cervix carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Oxysterol-binding protein-related protein 4L promotes cell proliferation by sustaining intracellular Ca2+ homeostasis in cervical carcinoma cell lines.
|
27588468 |
2016 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
The antiviral activity of TTP-8307 extends to other viruses that require OSBP, namely the picornavirus encephalomyocarditis virus and the flavivirus hepatitis C virus.
|
28088354 |
2017 |
|
Hypocholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
OSBP and Sac1 co-localized at apparent ER-Golgi contact sites in response to 25-hydroxycholesterol (25OH), cholesterol depletion and p38 MAPK inhibitors.
|
28471037 |
2017 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The role of oxysterol-binding protein and its related proteins in cancer.
|
28733164 |
2018 |
|
Primary malignant neoplasm
|
0.020 |
Biomarker
|
group |
BEFREE |
The role of oxysterol-binding protein and its related proteins in cancer.
|
28733164 |
2018 |
|
Hepatitis C
|
0.030 |
Biomarker
|
disease |
BEFREE |
RNA interference (RNAi)-mediated knockdown identified several hitherto unknown HCV dependency factors, such as steroidogenic acute regulatory protein-related lipid transfer domain protein 3 (STARD3), oxysterol-binding protein-related protein 1A and -B (OSBPL1A and -B), and Niemann-Pick-type C1 (NPC1), all residing at late endosome and lysosome membranes and required for efficient HCV RNA replication but not for replication of the closely related dengue virus.
|
29046459 |
2018 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
The facts that some natural anti-cancer molecules block OSBP and that many viruses hijack the OSBP cycle for the formation of intracellular replication organelles highlight the importance and potency of OSBP-mediated lipid exchange.
|
29596003 |
2018 |