OTX2, orthodenticle homeobox 2, 5015

N. diseases: 200; N. variants: 23
Disease: Stress, Psychological ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.020 GeneticVariation disease BEFREE Through unbiased transcriptomics and multiple molecular tools, transient downregulation of the Orthodenticle homeobox 2 (OTX2) gene was recently causatively associated with the development of depressive-like behaviors in a mouse model of early life stress. 30089883 2018
CUI: C0038443
Disease: Stress, Psychological
Stress, Psychological 		0.020 Biomarker disease BEFREE Early life stress confers lifelong stress susceptibility in mice via ventral tegmental area OTX2. 28619944 2017