P2RX4, purinergic receptor P2X 4, 5025

N. diseases: 138; N. variants: 6
Disease: Hyperalgesia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 Biomarker phenotype BEFREE P2 × 7 receptor-induced articular hyperalgesia is sustained by the involvement of this purinergic receptor in bradykinin and dopamine-induced hyperalgesia in the knee joint. 29260240 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 AlteredExpression phenotype BEFREE Results Repeated inflammatory dural stimulation induced trigeminal hyperalgesia and the upregulation of P2X4R. 30146940 2018
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.030 Biomarker phenotype BEFREE To the best of our knowledge, the present study provides evidence that spinal microglial P2X4R-BDNF signaling is critical for the development of NTW-induced hyperalgesia. 28306606 2017