P2RX5, purinergic receptor P2X 5, 5026

N. diseases: 132; N. variants: 6
Disease: Brain Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.020 Biomarker group BEFREE This review considers evidence suggesting that activation of the ionotropic purinergic receptor P2X<sub>7</sub> (P2X<sub>7</sub>R) is a contributing factor in the growth of brain tumors. 28536012 2017
CUI: C0006118
Disease: Brain Neoplasms
Brain Neoplasms 		0.020 Biomarker group BEFREE These results suggest that the efficacy of BBG in inhibiting tumor growth is primarily mediated by direct actions of the compound on P2X7R in glioma cells and that pharmacological inhibition of this purinergic receptor might serve as a strategy to slow the progression of brain tumors. 21157381 2011