P4HB, prolyl 4-hydroxylase subunit beta, 5034

N. diseases: 222; N. variants: 6
Disease: Neoplasm Metastasis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 AlteredExpression phenotype BEFREE HIF-1α and P4HB overexpression have a significant correlation with TNM staging (χ<sup>2</sup> = 23.32, <i>P</i> = 0.00; χ<sup>2</sup> = 65.64, <i>P</i> = 0.00) and peritoneum cavity metastasis (χ<sup>2</sup> = 12.67, <i>P</i> = 0.00; χ<sup>2</sup> = 39.29, <i>P</i> = 0.00). 29904245 2018
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 Biomarker phenotype BEFREE Although the molecular mechanism by which PDI contributes to tumorigenesis and metastasis remains to be understood, PDI is now emerging as a new therapeutic target for cancer treatment. 28648146 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.030 AlteredExpression phenotype BEFREE In addition, significant up-regulation of PDI A3 was detected only in the metastasized breast cancer. 22393307 2012