|
Heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
The Raf kinase inhibitor protein (RKIP) activates β-adrenoceptors (β-AR) and thereby induces a well-tolerated cardiac contractility and prevents heart failure in mice.
|
31604529 |
2019 |
|
Congestive heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
The Raf kinase inhibitor protein (RKIP) activates β-adrenoceptors (β-AR) and thereby induces a well-tolerated cardiac contractility and prevents heart failure in mice.
|
31604529 |
2019 |
|
Heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our results showed that a moderately increased cardiac protein level of RKIP was sufficient to induce major symptoms of heart failure in aged, 8-months-old RKIP-transgenic mice in two different genetic backgrounds.
|
30687708 |
2018 |
|
Congestive heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
Our results showed that a moderately increased cardiac protein level of RKIP was sufficient to induce major symptoms of heart failure in aged, 8-months-old RKIP-transgenic mice in two different genetic backgrounds.
|
30687708 |
2018 |
|
Heart failure
|
0.330 |
Biomarker
|
disease |
CTD_human |
Conversely, the dual-specific GRK2 and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg-regulated genes.
|
26670611 |
2016 |
|
Congestive heart failure
|
0.330 |
Biomarker
|
disease |
CTD_human |
Conversely, the dual-specific GRK2 and ERK cascade inhibitor, RKIP (Raf kinase inhibitor protein), triggered dysfunctional cardiomyocyte energetics and the expression of heart failure-promoting Pparg-regulated genes.
|
26670611 |
2016 |
|
Heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
Pebp1 gene transfer in a mouse model of heart failure has beneficial effects, suggesting a new therapeutic strategy for heart failure therapy.
|
26479924 |
2015 |
|
Congestive heart failure
|
0.330 |
Biomarker
|
disease |
BEFREE |
Pebp1 gene transfer in a mouse model of heart failure has beneficial effects, suggesting a new therapeutic strategy for heart failure therapy.
|
26479924 |
2015 |
|
Carcinoma
|
0.320 |
AlteredExpression
|
group |
BEFREE |
We found that RKIP expression was significantly decreased during malignant progression, being highly expressed in non-neoplastic tissues (54% of the samples; 73/135), and expressed at low levels in the cervix invasive carcinomas (∼15% (19/124).
|
23527098 |
2013 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
BEFREE |
Raf kinase inhibitory protein (RKIP) gene is considered to be a suppressor of metastasis involved in various carcinomas.
|
23066640 |
2012 |
|
Carcinoma
|
0.320 |
Biomarker
|
group |
CTD_human |
cDNA microarray profiling of rat mammary gland carcinomas induced by 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 7,12-dimethylbenz[a]anthracene.
|
12376462 |
2002 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.310 |
Biomarker
|
disease |
BEFREE |
Furthermore, p-RKIP was totally undetectable in both tissue and urine samples of ccRCC, showing a great potential for diagnostics purposes.Our data indicate that urinary RKIP encompasses both the unphosphorylated and the phosphorylated form and that their combined evaluation can help in the diagnosis and prognosis of ccRCC.
|
28418894 |
2017 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Left-Sided Heart Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
|
26670611 |
2016 |
|
Heart Failure, Right-Sided
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
|
26670611 |
2016 |
|
Myocardial Failure
|
0.300 |
Biomarker
|
disease |
CTD_human |
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
|
26670611 |
2016 |
|
Heart Decompensation
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Inhibition of G-protein-coupled Receptor Kinase 2 Prevents the Dysfunctional Cardiac Substrate Metabolism in Fatty Acid Synthase Transgenic Mice.
|
26670611 |
2016 |
|
Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Chromophobe Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Sarcomatoid Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Collecting Duct Carcinoma of the Kidney
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Papillary Renal Cell Carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Genetic variants in RKIP are associated with clear cell renal cell carcinoma risk in a Chinese population.
|
25329396 |
2014 |
|
Precancerous Conditions
|
0.300 |
Biomarker
|
group |
CTD_human |
Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.
|
21472284 |
2012 |
|
Condition, Preneoplastic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Hepatocellular carcinoma-associated protein markers investigated by MALDI-TOF MS.
|
21472284 |
2012 |
|
Myocardial Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Cardioplegia prevents ischemia-induced transcriptional alterations of cytoprotective genes in rat hearts: a DNA microarray study.
|
16214533 |
2005 |