NOX4, NADPH oxidase 4, 50507

N. diseases: 260; N. variants: 17
Disease: Ureteral obstruction ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 AlteredExpression phenotype BEFREE We generated transgenic mice specifically overexpressing mouse Nox4 in renal tubular cells and subjected the animals to the unilateral ureteral obstruction (UUO) model of fibrosis. 31247506 2019
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 Biomarker phenotype BEFREE Furthermore, our study revealed that TXNIP deficiency inhibited the expression of 8-OHdG, heme oxygenase-1 (HO-1) and NADPH oxidase 4 (Nox4) in UUO kidney. 29884908 2018
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 Biomarker phenotype BEFREE Furthermore, NOX4 increased in UUO mice and decreased with PR treatment. 28335679 2017
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 AlteredExpression phenotype BEFREE Nox4 expression in the obstructed kidney of UUO rat or in TGF-β1-stimulated NRK-52E was measured by quantitative RT-PCR and Western blotting. 28805491 2017
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 AlteredExpression phenotype BEFREE Moreover, Nox4, which is constitutively active in renal cells and is involved in the generation of hydrogen peroxide, was up-regulated during UUO-mediated fibrosis and induced by TGF-β1 in HK-2 cells, and this up-regulation could be blunted by Brd4 inhibition. 28063381 2017
CUI: C0041956
Disease: Ureteral obstruction
Ureteral obstruction 		0.060 AlteredExpression phenotype BEFREE These results indicated that CA attenuated oxidative stress via inhibition of Nox4 expression in TGF-β-stimulated fibroblasts and UUO operated-kidneys, suggesting that CA may be useful for the treatment of fibrosis-related diseases. 27212017 2016