PRDX1, peroxiredoxin 1, 5052

N. diseases: 237; N. variants: 3
Disease: Glioblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 AlteredExpression disease BEFREE We found that in diffuse astrocytoma, PRDX1 is highly expressed, and in glioblastoma, the expression level of <i>PRDX1</i> is low. 30322114 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 PosttranslationalModification disease BEFREE In contrast, IDH-wildtype astrocytic gliomas including glioblastomas mostly lack epigenetic silencing and express PRDX1 protein. 29582423 2018
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 Biomarker disease BEFREE Prevalences of mutations of isocitrate dehydrogenase 1 (IDH1) and histone H3.3 (H3F3A), the glioma cytosine-phosphate-guanine island methylator phenotype (G-CIMP), and methylation of alkylpurine DNA N-glycosylase (APNG) and peroxiredoxin 1 (PRDX1) promoters were determined in a representative biomarker subset (n = 126 patients with anaplastic astrocytoma or glioblastoma) from the NOA-08 trial. 23595628 2013
CUI: C0017636
Disease: Glioblastoma
Glioblastoma 		0.040 AlteredExpression disease BEFREE PRDX1 hypermethylation and reduced expression were frequently detected in oligodendroglial tumours and secondary glioblastomas, but not in primary glioblastomas. 22158042 2012