PRDX1, peroxiredoxin 1, 5052

N. diseases: 237; N. variants: 3
Disease: Carcinoma of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 Biomarker disease BEFREE Our findings suggest that Prx1 may modulate the chemosensitivity of lung cancer to docetaxel through suppression of FOXO1-induced apoptosis. 23615915 2013
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 AlteredExpression disease BEFREE Downregulation of peroxiredoxin I by a novel fully human phage display recombinant antibody induces apoptosis and enhances radiation sensitization in A549 lung carcinoma cells. 22022930 2012
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 AlteredExpression disease BEFREE Up-regulation of peroxiredoxin 1 in lung cancer and its implication as a prognostic and therapeutic target. 18413821 2008
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 AlteredExpression disease BEFREE We established stable transfectants of A549 (p53+) and H1299 (p53-) lung carcinoma cell lines with Prx I antisense to downregulate their Prx I protein. 16414373 2006
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 Biomarker disease BEFREE In this study, we further investigated the role of Prx I and p53 on lung cancer growth and the response to treatment in vitro and in vivo. 17084559 2006
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.060 Biomarker disease BEFREE There was also an increased amount of oxidized form of Prx I and a putative truncated form of Prx III in lung cancer samples when analysed on two-dimensional electrophoresis. 16635084 2006