|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings supported that PAI-1 rs1799889 polymorphism may serve as one of the predisposing factors of VTE in both Caucasians and East Asians, especially in these with DVT and these with Factor V Leiden mutation.
|
31701558 |
2019 |
|
Deep Vein Thrombosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.
|
29321050 |
2018 |
|
Deep Vein Thrombosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, small pulmonary emboli could be detected along with a mild phenotype of PA endothelial dysfunction and oxidative stress in the absence of PA-pressure elevation. mRNA expression of plasminogen activator inhibitor-1 was increased in PAs of mice with recurrent PE after repetitive thrombin injections and to a lesser extent in DVT mice.
|
29983855 |
2018 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The rs1799889 polymorphism located in the promoter region of the PAI-1 gene was detected in patients with deep venous thrombosis.
|
30334491 |
2018 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The PAI-1 4G/5G genotype was determined by real-Time PCR in 43 patients with unprovoked DVT of the lower limb.
|
28347810 |
2017 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the effects of arm-cranking exercise training on plasminogen activator inhibitor 1 (PAI-1) as a risk factor of deep vein thrombosis, along with general physical parameters such as muscle strength, aerobic capacity, and hemodynamics, in individuals with spinal cord injury (SCI) and control subjects.
|
28286201 |
2017 |
|
Deep Vein Thrombosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
These data not only confirm the role played by PAI-1 activity and by the 4G/5G SNP of the PAI-1 gene, but also suggest that current therapeutic protocols, recommending the administration of low weight molecular heparin and oral anticoagulant for the treatment of deep vein thrombosis, could be non sufficient for patients genetically predisposed to a less efficient clot lysis.
|
24485402 |
2014 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
PAI-1 4G/5G and MTHFR C677T polymorphisms increased the accuracy of two prediction scores for the risk of acute lower extremity deep vein thrombosis.
|
24715181 |
2014 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two are associated with thrombophilia (765 4G/5G and -844 A>G, in the promoter), risk of myocardial infarction and postoperative deep venous thrombosis related to higher than normal levels of PAI-1.
|
21663586 |
2011 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A 4G/5G polymorphism located in the promoter region of plasminogen activator inhibitor-1 (PAI-1) gene has been found to be commonly associated with the levels of PAI-1 and might be a risk factor for deep vein thrombosis (DVT).
|
19419975 |
2010 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of 4G allele for SERPINE1 was 0.538 for DVT, 0.555 for healthy participants, and 0.607 for OAD.
|
20017074 |
2009 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most prevalent polymorphisms were factor XIII V34L and PAI-1 4G/4G for both individuals with a history of deep vein thrombosis and recurrent pregnancy loss compared with controls.
|
18803625 |
2008 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine the incidence of deep venous thrombosis (DVT) recurrence in young people, and its association with some genetic polymorphisms (FV G1691A, FII G20210A, MTHFR C677T, PAI-1 4G/5G).
|
16061406 |
2005 |
|
Deep Vein Thrombosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hypofibrinolysis due to excess PAI-1 can be found in patients with deep vein thrombosis (DVT) and 4G/5G polymorphism of the PAI-1 gene may modulate the inhibitor's synthesis.
|
14653439 |
2003 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Single nucleotide polymorphisms of protein C, factor V (e.g., factor V Leiden), and plasminogen activator inhibitor-1 are associated with an increased risk of deep venous thrombosis, pulmonary emboli, acute myocardial infarction, and stroke.
|
12682447 |
2003 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results also showed significant differences in the plasma levels of PAI-1 antigen (ag) and PAI-1 act among the 4G/5G genotypes in DVT patients.
|
11091191 |
2000 |
|
Deep Vein Thrombosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the present work we studied the distribution of PAI-1 4G/5G genotype and its relation to fibrinolytic capacity in 70 unrelated patients with deep vein thrombosis.
|
9869167 |
1998 |
|
Deep Vein Thrombosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Therefore, PAI-1 gene promoter was screened for possibly new polymorphisms and to investigate the contribution of these sequence variations to PAI-1 levels in patients with deep vein thrombosis (DVT).
|
8987164 |
1996 |
|
Deep Vein Thrombosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Concerning postoperative DVT, preoperatively increased PAI-1 level seems to predict a postoperative DVT in patients subjected to hip surgery.
|
8578529 |
1995 |