SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Disease: Endometrial Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 GeneticVariation disease BEFREE Our data suggest that the level of PAI-1 and PAI-1 4G/5G gene polymorphism are effective in the formation of endometrial cancer. 28303356 2017
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 Biomarker disease BEFREE A significant increase in PAI-1 protein and mRNA was observed in endometrial cancer tissue in comparison with the endometrial tissue from control women (P<0.01). 22055623 2012
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 GeneticVariation disease BEFREE Individuals with PAI-1 rs1799889 4G/4G genotype were at significantly higher risk of endometrial cancer in this study. 21761413 2011
CUI: C0476089
Disease: Endometrial Carcinoma
Endometrial Carcinoma 		0.040 Biomarker disease BEFREE Therefore, sex steroidal induction of PAI-1 might contribute to the inhibition of invasion and metastasis, concomitantly with the inhibition of neovascularization associated with tPA and uPA activities, in well differentiated endometrial cancer. 9009232 1996