SERPINE1, serpin family E member 1, 5054

N. diseases: 770; N. variants: 23
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group BEFREE To evaluate whether uPA/PAI-1 protein in hormone receptor-positive (HR+) breast tumor can predict prognosis in early breast cancer (BC). 31132475 2019
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN The urokinase-system in tumor tissue stroma of the breast and breast cancer cell invasion. 19082473 2009
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 GeneticVariation group LHGDN PAI-1 -675 4G/5G polymorphism as a prognostic biomarker in breast cancer. 17616807 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group BEFREE In conclusion, the implementation of mRNA quantification of uPA and PAI-1 in breast tumors is unable to serve as a one-to-one substitution for antigen determination by ELISA. 18204793 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 GeneticVariation group LHGDN A comparison among HER2, TP53, PAI-1, angiogenesis, and proliferation activity as prognostic variables in tumours from 408 patients diagnosed with early breast cancer. 18465330 2008
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Expression of plasminogen activator inhibitors type 1 and type 3 and urokinase plasminogen activator protein and mRNA in breast cancer. 17258797 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 GeneticVariation group LHGDN Plasminogen activator inhibitor -1 gene 4G/5G polymorphism in patients with breast cancer. 17309181 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group BEFREE The aim of this study was to analyze uPA and PAI-1 messenger RNA (mRNA) expression by means of quantitative nucleic acid sequence-based amplification (NASBA) on 77 primary breast tumor samples and to correlate this expression with the uPA and PAI-1 protein content. 17709314 2007
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 GeneticVariation group LHGDN Prognostic value of PAI1 in invasive breast cancer: evidence that tumor-specific factors are more important than genetic variation in regulating PAI1 expression. 17119035 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 GeneticVariation group LHGDN Functional plasminogen activator inhibitor-1 gene variants and breast cancer survival. 17062678 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Prognostic significance of urokinase plasminogen activator and plasminogen activator inhibitor-1 mRNA expression in lymph node- and hormone receptor-positive breast cancer. 16945123 2006
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN The prognostic value of vascular endothelial growth factor, urokinase plasminogen activator and plasminogen activator inhibitor-1 in node-negative breast cancer. 15646834 2005
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN Urokinase-type plasminogen activator (uPA) and its inhibitor PAI-I: novel tumor-derived factors with a high prognostic and predictive impact in breast cancer. 14983219 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 Biomarker group LHGDN The complex between urokinase-type plasminogen activator (uPA) and its type-1 inhibitor (PAI-I) independently predicts response to first-line endocrine therapy in advanced breast cancer. 14983227 2004
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group LHGDN Independent prognostic value of angiogenesis and the level of plasminogen activator inhibitor type 1 in breast cancer patients. 12556967 2003
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms
0.100 AlteredExpression group BEFREE A suppression subtraction cDNA library representing mRNAs expressed at a higher level in a benign breast tumour-derived cell line relative to the malignant MCF-7A cell line contained cDNAs corresponding to mRNAs for plasminogen activator inhibitor I, annexin VIII and the EF-hand protein S100A2. 11076656 2000