Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We analyzed levels of IL-20 receptor subunit A (IL-20RA), CD55, and receptor activator of nuclear factor kappaB (NF-κB) ligand (RANKL) in RA fibroblast-like synoviocytes (FLSs) using confocal microscopy.
|
31831038 |
2019 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The IL-20 Cytokine Family in Rheumatoid Arthritis and Spondyloarthritis.
|
30319661 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory bone disorders likes intervertebral disc herniation, rheumatoid arthritis (RA), osteoporosis, and bone fracture.
|
30250404 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is emerging as a potent angiogenic, chemotactic, and proinflammatory cytokine related to several chronic inflammatory disorders likes psoriasis, atherosclerosis, cancer, liver fibrosis, and RA.
|
29690863 |
2018 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This review focuses on current knowledge of IL-20's involvement in the pathogenesis of rheumatoid arthritis.
|
26297177 |
2017 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of IL-20 in RA synovial tissue was particularly associated with macrophages and neutrophil granulocytes, but also with synovial fibroblasts and lymphocytes.
|
28662439 |
2017 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Elucidation of this interaction provides a better understanding of cytokine cross-talk in RA and a rationale for more effective biologic therapies that target IL-20R2 instead of individual cytokines from IL-20 family.
|
27619991 |
2016 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results highlight the importance of gene assignment for translating GWAS findings into biologically meaningful mechanisms of disease and potential therapeutic targets; indeed, monoclonal antibody therapy targeting IL-20 is effective in the treatment of rheumatoid arthritis and psoriasis, both with strong GWAS associations to this region.
|
27799070 |
2016 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Recent evidence indicates that IL-20's interaction with its receptors might have proinflammatory effects on chronic inflammatory diseases, particularly rheumatoid arthritis (RA), osteoporosis, and breast cancer.
|
24816455 |
2014 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the present review, we focus on IL-7, IL-18, IL-32 and IL-10 family of cytokines (IL-19, IL-20 and IL-22) as they are implicated in contributing to the pathogenesis of RA, which could be targeted and offer new therapeutic options for RA therapy.
|
24437572 |
2014 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and IL-22 mRNA levels were also upregulated in RA SFMCs but their level of expression was lower than that of IL-10 or IL-19.
|
20001767 |
2010 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
LHGDN |
IL-20 was increased in plasma of rheumatoid arthritis patients compared with osteoarthritis patients and IL-24 was increased in synovial fluid and plasma of rheumatoid arthritis and spondyloarthropathy patients compared with osteoarthritis patients.
|
18061474 |
2008 |
Rheumatoid Arthritis
|
0.100 |
Biomarker
|
disease |
BEFREE |
IL-20 is involved in inflammatory diseases such as psoriasis, atherosclerosis, and rheumatoid arthritis, etc.
|
18758357 |
2008 |
Rheumatoid Arthritis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
IL-20 and its receptors were detected in RA synovial fibroblasts (RASFs), using immunohistochemical staining.
|
16947773 |
2006 |