Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Finally, BXSB-Yaa mice, which develop a systemic lupus erythematosus-like disease, have greatly elevated IL-21, suggesting a role for IL-21 in the development of autoimmune disease.
|
15494482 |
2004 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Also, the studies on the production of IL-21 in human autoimmune diseases and its behaviour on human cells in vitro are revealing the potential of IL-21 to exacerbate cellular processes that determine the course of autoimmune diseases.
|
18508588 |
2008 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Co-expression of IL-22 and IL-17 has been identified and demonstrated to be involved in the immunopathogenesis of some autoimmune diseases as well as the defense against pathogenic infections in animal studies.
|
19449309 |
2009 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
We propose that, by driving cycles of T cell expansion and apoptosis to excess, IL-21 increases the stochastic opportunities for T cells to encounter self antigen and, hence, for autoimmunity.
|
19546505 |
2009 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Th cell cytokines IL-17A and IL-21 have been assigned with pivotal roles in the regulation of such autoimmune diseases.
|
19748983 |
2009 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21 is therefore an autocrine cytokine that regulates human Th17 cells in rheumatoid arthritis, and serves as a good target for treating this autoimmune disease.
|
20079789 |
2010 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results provide the rationale for further evaluation of the therapeutic potential of IL-21 in certain AD such as SLE.
|
20394077 |
2010 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Many studies have reported that IL-21 has crucial roles in autoimmune diseases.
|
22057994 |
2011 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In particular the crucial role of NF-AT detected herein may form the basis of direct action of CsA on IL-22 expression by T cells, which may contribute to therapeutic efficacy of the drug in autoimmunity.
|
22170067 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin 22 (IL-22), a relatively new cytokine has been found to induce significant proliferation of human keratinocytes and fibroblast like synoviocytes (FLS) and thus plays an important role in the pathogenesis of autoimmune diseases like psoriasis and rheumatoid arthritis (RA) which are characterized by hyperproliferation of keratinocytes and FLS respectively.
|
22840496 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Using a mouse model for multiple sclerosis, here we show that B10-cell maturation into functional IL-10-secreting effector cells that inhibit in vivo autoimmune disease requires IL-21 and CD40-dependent cognate interactions with T cells.
|
23064231 |
2012 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Taken together, SLV appears to be a Th1-polarized autoimmune disease, whereby IFN-γ expression is strongly associated with parallel increases in IL-10 and IL-21, particularly during early and active stages of SLV.
|
22113479 |
2012 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-17 and IL-22 are implicated in the pathogenesis of autoimmune diseases.
|
23617779 |
2013 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, secrete IL-21 whose augmented secretion is a hallmark of several autoimmune diseases.
|
24411167 |
2014 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IL22RA2 represents a compelling MS candidate gene due to the role of IL-22 in autoimmunity; however, rs17066096 does not map into any known functional element.
|
24638856 |
2014 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the newly determined interleukin (IL)‑22‑producing T-helper (Th) 22 cell has been implicated to be involved in the pathogenesis of autoimmune diseases.
|
24737285 |
2014 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases.
|
25894310 |
2015 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: a meta-analysis.
|
25074442 |
2015 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy.
|
26923718 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21 also affects different subtypes of T cells including T helper-17 (TH17), T follicular helper (TFH) and regulatory T (Treg) cells and thereby promotes the development of autoimmune disorders and inflammatory diseases.
|
26466984 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-22 (IL-22) as the signature cytokine of T helper 22 cells is increasingly recognized as a key regulator in various autoimmune diseases.
|
26711064 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
|
28283529 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Th22 cells and IL-22 were correlated with inflammatory and autoimmune diseases.
|
27548078 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we assess the current understanding of this cytokine and focus on the possible roles of IL-22 in autoimmune diseases.
|
29037907 |
2017 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared with age-matched healthy controls, children with autoimmunity had lower numbers and frequencies of B10 cells (decreased by 39% and 48%, respectively), higher IFNγ levels, and lower IL-21 levels in serum.
|
27429419 |
2017 |