Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinical significance and immunobiology of IL-21 in autoimmunity.
|
30773373 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Plasma cytokine analysis confirms elevation of multiple autoimmunity-related cytokines (e.g., TNF-α, IL17A-D, IL-22) in people with DS, independent of diagnosis of autoimmunity.
|
31699819 |
2019 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients who have developed autoimmunity also show a high basal level of IL-21, a cytokine which increases the growth of auto-reactive T-cells.
|
31371976 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
This study therefore elucidates critical mechanism for IL-21-induced Th17 differentiation to indicate SKI and SMAD4 as potential therapeutic targets for treating autoimmune diseases.
|
31398665 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21 is a pleiotropic cytokine that plays a key role in modulating inflammatory responses, including the promotion of autoimmune diseases.
|
30590020 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin 22 ameliorates neuropathology and protects from central nervous system autoimmunity.
|
31080013 |
2019 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Accordingly, SFN significantly inhibited the activation of untransformed human T-cells derived from healthy donors or RA patients, and downregulated the expression of the transcription factor RORγt, and the T<sub>H</sub>17-related cytokines IL-17A, IL-17F, and IL-22, which play a major role within the pathophysiology of many chronic inflammatory/autoimmune diseases.
|
30487791 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Although the early studies on IL-17 focused on Th17 cells, it was later demonstrated that γδ T cells were an important early source of IL-17 and IL-21 that helped amplify IL-17 production by Th17 cells in autoimmune diseases.
|
29395738 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-22 is one of the member of IL-10 cytokine family, and several studies have implicated IL-22 signaling in the pathogenesis of autoimmune diseases.
|
29336866 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-22, a potent target for treatment of non-autoimmune diseases.
|
30335564 |
2018 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Deregulated production of interleukin (IL)-17 and IL-21 contributes to the pathogenesis of autoimmune disorders such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA).
|
28283529 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Th22 cells and IL-22 were correlated with inflammatory and autoimmune diseases.
|
27548078 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In this review, we assess the current understanding of this cytokine and focus on the possible roles of IL-22 in autoimmune diseases.
|
29037907 |
2017 |
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Compared with age-matched healthy controls, children with autoimmunity had lower numbers and frequencies of B10 cells (decreased by 39% and 48%, respectively), higher IFNγ levels, and lower IL-21 levels in serum.
|
27429419 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, our study identifies miR-146a as an important molecular brake that blocks the autocrine IL-6- and IL-21-induced Th17 differentiation pathways in autoreactive CD4 T cells, highlighting its potential as a therapeutic target for treating autoimmune diseases.
|
28872459 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-22 provides a new insight into the mechanisms of autoimmunity, and copy number variations (CNVs) are associated with autoimmune diseases.
|
28716697 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Our work provides mechanistic insight into the contribution of IL-21 to the pathogenesis of murine lupus, while revealing the importance of T-B cellular cross-talk in mediating autoimmunity, demonstrating that its interruption impacts both cell types leading to disease amelioration.
|
28219887 |
2017 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, accumulating evidence has defined both protective and pathogenic properties of IL-22 in a number of conditions including autoimmune disease, infection, and malignancy.
|
26923718 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21 also affects different subtypes of T cells including T helper-17 (TH17), T follicular helper (TFH) and regulatory T (Treg) cells and thereby promotes the development of autoimmune disorders and inflammatory diseases.
|
26466984 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-22 (IL-22) as the signature cytokine of T helper 22 cells is increasingly recognized as a key regulator in various autoimmune diseases.
|
26711064 |
2016 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The follicular helper T cell (Tfh) and IL-21 have been shown to play an important role in many autoimmune diseases.
|
25894310 |
2015 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Association of IL-21 polymorphisms (rs907715, rs2221903) with susceptibility to multiple autoimmune diseases: a meta-analysis.
|
25074442 |
2015 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Follicular helper T cells (Tfh), which play a pivotal role in B cell activation and differentiation in lymphoid structures, secrete IL-21 whose augmented secretion is a hallmark of several autoimmune diseases.
|
24411167 |
2014 |
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IL22RA2 represents a compelling MS candidate gene due to the role of IL-22 in autoimmunity; however, rs17066096 does not map into any known functional element.
|
24638856 |
2014 |
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Recently, the newly determined interleukin (IL)‑22‑producing T-helper (Th) 22 cell has been implicated to be involved in the pathogenesis of autoimmune diseases.
|
24737285 |
2014 |