IL22, interleukin 22, 50616

N. diseases: 551; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 GeneticVariation group BEFREE We investigated associations between single nucleotide polymorphisms (SNPs) in the IL22 gene (rs1026788, rs2227472, rs2227491, rs2227485, rs1179249, rs2046068,rs2227473, and rs7314777) and the risk of HBV-related chronic liver diseases within a Han population in Northeast China. 31689880 2019
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 Biomarker group BEFREE We engineered <i>Lactobacillus reuteri</i> to produce IL-22 (<i>L. reuteri</i>/IL-22) and fed them to mice along with the ethanol diet; these mice had reduced liver damage, inflammation and bacterial translocation to the liver compared with mice fed an isogenic control strain and upregulated expression of REG3G in intestine.However, <i>L. reuteri</i>/IL-22 did not reduce ethanol-induced liver disease in <i>Reg3g<sup>-/-</sup></i> mice. 30448775 2019
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 Biomarker group BEFREE Since Th17-associated cytokines are associated with the progression of liver disease in HCV patients, IL-17A and IL-21 can be used as important biological markers for evaluating the immunopathogenesis of chronic hepatitis. 29147974 2018
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 AlteredExpression group BEFREE In summary, IL-21 has a causal role in the development of severe liver inflammation, which is upregulated in HB-ACLF and associated with severity of liver disease. 21692955 2011
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 AlteredExpression group BEFREE To clarify the role of IL-22 up-regulation in the pathogenesis of liver diseases, liver-specific IL-22 transgenic (IL-22TG) mice, under the control of albumin promoter, were developed. 21465510 2011
CUI: C0023895
Disease: Liver diseases
Liver diseases
0.060 Biomarker group BEFREE In conclusion, hydrodynamic gene delivery of IL-22 protects against liver injury induced by a variety of toxins, suggesting the therapeutic potential of IL-22 in treating human liver disease. 16212920 2004