|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We found levels of IL22 to be increased during pancreatitis and pancreatic tumor development, and to be required for tumor development and progression in mice.
|
31843590 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For the first time, this study provides an insight into the tumor stage-specific function of IL-22 in breast tumorigenesis.
|
31725949 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-17 and IL-22, Th17-derived cytokines, influence the tumor microenvironment by directly promoting transformed cell properties and neighboring stromal cell activity.
|
30941641 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the frequency of IL-21-producing CD8+CXCR5+ T cells was higher in HCC tumor tissue than in peritumoral tissue or peripheral blood from the same patients or in blood from healthy donors.
|
31663864 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Vaccination with irradiated cells overexpressing GM-CSF or IL-21 alone significantly inhibited tumor growth and led to significantly more CD4<sup>+</sup> CD8<sup>+</sup> T cells and fewer CD4<sup>+</sup> Foxp3<sup>+</sup> T cells in the spleen and xenograft.
|
31467912 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
ILC3s produce IL-22, which could promote tumor growth.
|
31024531 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data indicated that IL22 serves a critical role in the malignant transformation of rat MSCs, which is associated with an enhancement of the IL22RA1/STAT3 signaling pathway in the tumor microenvironment.
|
30816520 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-22 enhances tumor growth and induces chemotherapy resistance in human lung cancer cells.
|
31750252 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunohistochemistry studies were performed to evaluate LES myofilaments obtained from both groups, as well as from 12 patients diagnosed with a subendothelial non-invasive tumor and who had undergone submucosal tunneling endoscopic resection, to assess the expression of interleukin-17 and interleukin-22 in LES myofilaments.
|
29806597 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We will summarize here the diverse roles of IL-22 for the malignant transformation of epithelial cells, for tumor growth, wound healing and tissue repair.
|
29178520 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-22 protein levels in tumor tissues were examined using immunohistochemistry.
|
29928409 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
There is some controversy as for the roles played by tumor growth factor-β (TGF-β), interleukin-1β (IL-1β), and IL-22 in the onset process of type 2 diabetes (T2D).
|
29953655 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we found that CSA drives SCC proliferation and tumor growth through IL-22 and JAK/STAT pathway induction.
|
30185657 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Finally, we showed that the transcriptional levels of IL-21 in the peritumoral region and IL-21R within the tumor are associated with survival and recurrence of HCC patients.
|
30524894 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21 Increases the Reactivity of Allogeneic Human Vγ9Vδ2 T Cells Against Primary Glioblastoma Tumors.
|
29683891 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IL-21-secreting hUCMSCs combined with miR-200c inhibit tumor growth and metastasis via repression of Wnt/β-catenin signaling and epithelial-mesenchymal transition in epithelial ovarian cancer.
|
29692616 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-22 expression and <i>RORγt/AhR</i> mRNA in BALF was also remarkably increased in tumor site.
|
30473538 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, when present in the tumor microenvironment, IL-21 might negatively impact γδ T cell anti-tumor functions.
|
29296543 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Relevant to ongoing clinical trials in breast cancer, we demonstrate here that the IL-1 receptor antagonist anakinra abrogates IL-22 production and reduces tumor growth in a murine breast cancer model.
|
29150554 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interleukin-22 (IL-22) is a well-known tumor related inflammatory factor that is associated with variety of cancers.
|
29262587 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, the recovery of NK-cell function by IL-21 is critical for the anti-tumour effects of the vaccine against advanced tumours.
|
28585539 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The purpose of this study is to evaluate the efficacy of <i>ex vivo</i> expanded human NK cells in controlling primary and metastatic ES tumor growth <i>in vitro</i> and <i>in vivo.</i> Using membrane-bound IL-21 containing K562 (K562-mbIL-21) expansion platform, we were able to obtain sufficient numbers of expanded NK (eNK) cells that display favorable activation phenotypes and inflammatory cytokine secretion, along with a strong <i>in vitro</i> cytotoxic effect against ES.
|
28507811 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Double immunofluorescence observations confirmed that IL-21 positive cells were mostly natural killer cells and T lymphocytes in the tumor stroma.
|
28887120 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IL-22 and IL-22R1 mRNA displayed no differences in tumor and healthy tissue.
|
26797799 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In contrast, the administration of IL-15 and IL-21 in combination with CART cells in vivo increased their tumor killing capacity.
|
27409425 |
2016 |