|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
Biomarker
|
disease |
BEFREE |
We compared rats with late-onset T2D that display pancreatic and cardiac phenotypes similar to those in humans with T2D (HIP rats) and their nondiabetic littermates (wild type [WT]).
|
30414461 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
GeneticVariation
|
disease |
BEFREE |
Pregnancy can therefore be considered a stress test; diagnosis of HIP can unmask a preexisting susceptibility and consequently a future risk for type 2 diabetes and can be a useful marker of future cardiovascular risk.
|
29730389 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
GeneticVariation
|
disease |
BEFREE |
We report that circadian activity, light-induced entrainment, molecular clockwork, as well as melatonin secretion are preserved in the HIP rat model of T2DM.
|
28465284 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
AlteredExpression
|
disease |
BEFREE |
However, reduced LPIN1 and PAP1 activity has been described in participants with type 2 diabetes.
|
27344312 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
Biomarker
|
disease |
RGD |
Regenerating 1 and 3b gene expression in the pancreas of type 2 diabetic Goto-Kakizaki (GK) rats.
|
24587207 |
2014 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
AlteredExpression
|
disease |
BEFREE |
Here, we studied cardiac PAP(1) activity and lipin expression ex vivo in 8-month-old Zucker diabetic fatty (ZDF) rats and humans with type 2 diabetes mellitus undergoing open heart surgery for coronary bypass grafting.
|
19799857 |
2009 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.260 |
Biomarker
|
disease |
BEFREE |
The HIP rat provides additional evidence in support of the potential role of IAPP oligomer formation toward the increased frequency of apoptosis in type 2 diabetes, a process that appears to be compounded by glucose toxicity when hyperglycemia supervenes.
|
15161755 |
2004 |
|
Acute pancreatitis
|
0.210 |
ModifyingMutation
|
disease |
RGD |
Small-interference RNA gene knockdown of pancreatitis-associated proteins in rat acute pancreatitis.
|
18437087 |
2008 |
|
Acute pancreatitis
|
0.210 |
Biomarker
|
disease |
BEFREE |
Pancreatitis-associated protein I (PAP I) is a secretory protein first described as an acute phase reactant during acute pancreatitis.
|
8956791 |
1996 |
|
Sciatic Neuropathy
|
0.200 |
Biomarker
|
disease |
RGD |
Patterns of pain: meta-analysis of microarray studies of pain.
|
21561713 |
2011 |
|
Visual seizure
|
0.200 |
Biomarker
|
disease |
RGD |
Pancreatitis-associated protein-I and pancreatitis-associated protein-III expression in a rat model of kainic acid-induced seizure.
|
21093549 |
2011 |
|
Pneumonia
|
0.200 |
Biomarker
|
disease |
RGD |
The pancreatitis-associated protein induces lung inflammation in the rat through activation of TNFalpha expression in hepatocytes.
|
12579542 |
2003 |
|
Pancreatitis, Chronic
|
0.200 |
Biomarker
|
disease |
RGD |
Secretory apparatus assessed by analysis of pancreatic secretory stress protein expression in a rat model of chronic pancreatitis.
|
12764608 |
2003 |
|
Pancreatitis, Chronic
|
0.200 |
Therapeutic
|
disease |
RGD |
Expression of pancreatitis-associated protein (PAP) in rat spontaneous chronic pancreatitis: effect of herbal medicine Saiko-keishi-to (TJ-10).
|
10505754 |
1999 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Reg3A is upregulated during pancreatic inflammation and exhibits a pro-growth function and may thus serve a critical role during inflammation-driven PaC malignancies.
|
31572529 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
All asymptomatic individuals underwent screening investigations for malignancy including PAP smear, mammography, low-dose computed tomography, evaluation of cancer antigen 125, cancer antigen 19-9, alpha fetoprotein, carcinoembryonic antigen, prostate specific antigen (PSA) levels and clinical examination to identify healthy individuals with no indication of cancer.
|
31785151 |
2019 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For this purpose, raw RT-qPCR data for 25 candidate microRNAs, U6 snRNA and human DNA in air-dried PAP smears from 174 women with different cervical cytological diagnoses, 144 of which were HR-HPV-positive [40 negative for intraepithelial lesion or malignancy (NILM), 34 low-grade squamous intraepithelial lesions (L-SIL), 57 high-grade squamous intraepithelial lesions (H-SIL), 43 invasive cancers], were statistically processed.
|
29328473 |
2018 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Gene set enrichment analysis on The Cancer Genome Atlas dataset showed that Kyoto Encyclopedia of Genes and Genomes (KEGG) DNA replication and base excision repair (BER) pathways were correlative with the REG3A expression, which was further confirmed in CRC cells by Western blot.
|
26646797 |
2016 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We previously reported that regenerating islet-derived protein 3 alpha (REG3A) exacerbates pancreatic malignancies.
|
26719042 |
2016 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Regenerating islet-derived protein 3-alpha (Reg3A) has been reported overexpressed in pancreatic inflammation and associated with PaC malignancies, thus believed as a potential target in inflammation-linked pancreatic carcinogenesis.
|
24996521 |
2014 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we report for the first time that Psora-4, PAP-1 and clofazimine, three distinct membrane-permeant inhibitors of Kv1.3, induce death by directly targeting the mitochondrial channel in multiple human and mouse cancer cell lines.
|
22496117 |
2012 |
|
Malignant Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we show that HMGB1 increases the expression of miR-221 and miR-222 in primary cultures of excised papillary lesions and in an established papillary cancer cell line (BC PAP).
|
23023232 |
2012 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This method was applied to 40 archival smears from ten cervical cancer patients (selected from a group of 200 patients) which had a history of 3-6 smears with the first smear being Pap 1 or 2 taken at least 5 years before cancer was diagnosed.
|
10780521 |
2000 |
|
Malignant Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Three genes encoding related proteins, PAP, reg Ialpha and reg Ibeta, were over-expressed in cancer.
|
10328217 |
1999 |
|
Pancreatitis
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Reg3A is upregulated during pancreatic inflammation and exhibits a pro-growth function and may thus serve a critical role during inflammation-driven PaC malignancies.
|
31572529 |
2019 |