Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The histological diagnosis was alveolar (RMA) (n = 38, 23/25 examined patients PAX7/3:FOXO1-positive), embryonal (RME) (n = 100), botryoid (n = 10), anaplastic (n = 1), and spindle-cell RMS (n = 6).
|
30762282 |
2019 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Only the ten biopsies involved by Ewing sarcoma and four biopsies with rhabdomyosarcoma showed strong nuclear PAX7 staining.
|
30014288 |
2018 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent tissue microarray studies suggested that PAX7 is a novel marker, because it was expressed consistently in Ewing sarcoma, in addition to rhabdomyosarcoma and synovial sarcoma.
|
29920735 |
2018 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We previously demonstrated PAX7 expression as a marker of skeletal muscle differentiation in rhabdomyosarcoma.
|
28643791 |
2017 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Specifically, we determined that PAX7 downregulation is necessary for miR-206-induced cell cycle exit and myogenic differentiation in FN-RMS but not in FP-RMS.
|
27277678 |
2016 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
For treatment stratification, RMS is further subclassified as fusion-positive (FP-RMS) or fusion-negative (FN-RMS), depending on whether a gene fusion involving PAX3 or PAX7 is present or not.
|
26482321 |
2016 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In our studies we employed eight rhabdomyosarcoma (RMS) cell lines (three alveolar-type RMS cell lines and five embrional-type RMS cell lines), and mRNA samples obtained from positive, PAX7-FOXO1-positive, and fusion-negative RMS patient samples.
|
26412593 |
2015 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rhabdomyosarcoma (RMS) is the most common pediatric soft tissue sarcoma and includes a PAX3- or PAX7-FOXO1 fusion-positive subtype.
|
25810375 |
2015 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
One major subgroup of RMS tumors (so-called "fusion-positive" tumors) carries exclusive chromosomal translocations that join the DNA-binding domain of the PAX3 or PAX7 gene to the transactivation domain of the FOXO1 (previously known as FKHR) gene.
|
25368019 |
2014 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Rhabdomyosarcoma (RMS) is divided into two major histological subtypes: alveolar (ARMS) and embryonal (ERMS), with most ARMS expressing one of two oncogenic genes fusing PAX3 or PAX7 with FOXO1 (P3F and P7F, respectively).
|
23526739 |
2013 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Convenience cohorts have been used to investigate the prognostic significance of chromosomal translocations between the PAX3 or PAX7 and the FOXO1 genes in rhabdomyosarcoma, the most common pediatric sarcoma.
|
22564868 |
2012 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, MDR3 was significantly associated with the presence of PAX3/PAX7-FKHR transcripts in RMS (p<0.05).
|
22504834 |
2012 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using immunohistochemistry, we characterized two markers, HMGA2 and TFAP2ss, which facilitate the differential diagnoses of ERMS and P-F RMS, respectively, using clinical material.
|
19147825 |
2009 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, RMS-II represents a promising peptide for the development of RMS-specific targeting approaches.
|
19123480 |
2009 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study is to identify immunohistochemical markers of potential prognostic significance in pediatric RMS and to correlate their expression with PAX-3/FKHR and PAX-7/FKHR fusion status.
|
18708938 |
2008 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A less frequent variant translocation t(1;13) involves another PAX family gene, /PAX7/, located in chromosome 1 and /FOXO1/ and is present in 10-15% of cases of the alveolar subtype in RMS.
|
17652054 |
2007 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Real-time RT-PCR assays specific for Ewing's sarcoma (EWS-FLI1, EWS-ERG, EWS-ETV1, EWS-ETV4, and EWS-FEV), synovial sarcoma (SYT-SSX1 and SYT-SSX2), and rhabdomyosarcoma (PAX3-FKHR and PAX7-FKHR) were tested across the samples.
|
17334332 |
2007 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The most common types of rhabdomyosarcoma (RMS) are alveolar RMS (ARMS), which are characterized by the specific translocation t(2;13)(q35;q14) or its rarer variant, t(1;13)(p36;q14), producing the fusion genes PAX3-FKHR and PAX7-FKHR, respectively, and embryonal RMS (ERMS), which is characterized by multiple numeric chromosome changes.
|
16337856 |
2005 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In conclusion, these studies reveal that PAX3, PAX7 and their fusions with FKHR are each expressed in RMS tumors as a consistent mixture of functionally distinct isoforms.
|
15688409 |
2005 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
FOXO1 gene is fused to PAX3 or PAX7 genes in rhabdomyosarcoma.
|
15492844 |
2004 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, Fos is able to repress Pax7 expression in rhabdomyosarcoma cell lines and primary myoblasts, suggesting a molecular link to genetic alterations involved in human rhabdomyosarcomas.
|
14706339 |
2003 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
This is corroborated by the detection of MET (c-met) expression, a marker for the myogenic satellite cell lineage, in all RMS samples expressing wild-type PAX7.
|
12865925 |
2003 |
Adult Rhabdomyosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We also observed that cell lines derived from alveolar RMS, which is characterized by recurrent PAX3- and PAX7-FKHR gene fusions and is associated with a poor prognosis, expressed higher levels of CXCR4 than lines derived from embryonal RMS.
|
12239174 |
2002 |
Adult Rhabdomyosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined PAX3-FKHR or PAX7-FKHR fusion status in 171 childhood rhabdomyosarcoma (RMS) patients entered onto the Intergroup Rhabdomyosarcoma Study IV, including 78 ARMS patients, using established reverse transcriptase polymerase chain reaction assays.
|
12039929 |
2002 |
Adult Rhabdomyosarcoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The availability of an ARMS cell line that harbors the t(1;13)(p36;q14) constitutes a useful tool for further understanding the role of the PAX7-FKHR fusion gene in RMS oncogenesis and may improve knowledge of the possible relation between PAX7-FKHR and MYCN amplification.
|
11063797 |
2000 |