|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia.
|
1520867 |
1992 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
New E2A/PBX1 fusion transcript in a patient with t(1;19)(q23;p13) acute lymphoblastic leukemia.
|
8103813 |
1993 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes.
|
7769844 |
1995 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Monoclonal antibodies specific to the acute lymphoblastic leukemia t(1;19)-associated E2A/pbx1 chimeric protein: characterization and diagnostic utility.
|
9108411 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Hyperdiploidy and E2A-PBX1 fusion in an adult with t(1;19)+ acute lymphoblastic leukemia: case report and review of the literature.
|
9408756 |
1997 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have examined differences in the engraftment patterns in SCID mice of primary human leukemic cells isolated from children (< 21 years old) with either t(1;19)+/E2A-PBX1+ or t(9;22)+/BCR-ABL+ acute lymphoblastic leukemia.
|
10037003 |
1998 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(1;19) translocation yields a fusion between E2A and PBX1 genes and occurs in 5% of acute lymphoblastic leukemia in children and adults.
|
12415113 |
2002 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia].
|
16215946 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ZAP-70 expression in acute lymphoblastic leukemia: association with the E2A/PBX1 rearrangement and the pre-B stage of differentiation and prognostic implications.
|
16160012 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children.
|
18024406 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both genes are known to be targeted also by other neoplasia-specific translocations, PBX1 in acute lymphoblastic leukemia and EWSR1 in several solid tumors, most of which are malignant.
|
18383210 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients.
|
18455790 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study.
|
19587702 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche.
|
19922767 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
E2A, 1 of 3 E-protein-encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein.
|
22972988 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In E2A-PBX1-positive B-ALLs, aberrant DNA methylation patterning was strongly associated with direct fusion protein binding as shown by the E2A-PBX1 chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq), suggesting that E2A-PBX1 fusion protein directly remodels the epigenome to impose an aggressive B-ALL phenotype.
|
23107779 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia.
|
23044487 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL).
|
23688269 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study reviewed the clinical characteristics of 112 pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients with TCF3-PBX1 fusion treated according to the Japan Association of Childhood Leukemia Study (JACLS) ALL02 protocol (n = 82) and Children's Cancer and Leukemia Study Group (CCLSG) ALL 2004 protocol (n = 30).
|
24578304 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For example, whereas the E2A portion of the E2A-Pbx1 leukemia fusion protein mediates robust transcriptional activation in t(1;19) acute lymphoblastic leukemia, the transcriptional activity of wild-type E2A is silenced by high levels of corepressors, such as the AML1-ETO fusion protein in t(8;21) acute myeloid leukemia and ETO-2 in hematopoietic cells.
|
24064250 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
|
26301816 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical features and prognostic significance of TCF3-PBX1 fusion gene in Chinese children with acute lymphoblastic leukemia by using a modified ALL-BFM-95 protocol.
|
25551271 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Investigation for TCF3(E2A)-PBX1 rearrangements may be useful in BCL6-positive B-lymphoblastic leukemia.
|
25780007 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.
|
27088431 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.
|
27758892 |
2016 |