|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although survival rate is usually high after the initial chemotherapy, many TCF3-PBX1 BCP-ALL patients relapse and subsequently develop treatment resistance, resulting in poor prognosis.
|
30631148 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our findings suggest that anti-CD19 CAR-T cells therapy with a remarkable MRD eradicating ability might be an effective option for patients with relapsed and refractory E2A-PBX1 positive B-ALL.
|
30714847 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
t(17;19)(q21-q22;p13), responsible for TCF3-HLF fusion, is a rare translocation in childhood B-cell precursor acute lymphoblastic leukemia(BCP-ALL). t(1;19)(q23;p13), producing TCF3-PBX1 fusion, is a common translocation in childhood BCP-ALL.
|
31305009 |
2019 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A novel PAX5 rearrangement in TCF3-PBX1 acute lymphoblastic leukemia: a case report.
|
30563523 |
2018 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
TCF3-PBX1 BCP-ALL patients typically benefit from chemotherapy; however, many relapse and subsequently develop resistant disease with few effective treatment options.
|
27461063 |
2017 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Identification of cooperative genes for E2A-PBX1 to develop acute lymphoblastic leukemia.
|
27088431 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
E2A-PBX1 Remodels Oncogenic Signaling Networks in B-cell Precursor Acute Lymphoid Leukemia.
|
27758892 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We reviewed the roles of miRNA here with emphasis on their function in human leukemia and the mechanisms of the TEL/AML1, BCR/ABL, MLL/AF4 and TCF3/PBX1 oncoproteins on miRNAs expression in acute lymphoblastic leukemia.
|
27431573 |
2016 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Comparative genomics reveals multistep pathogenesis of E2A-PBX1 acute lymphoblastic leukemia.
|
26301816 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Clinical features and prognostic significance of TCF3-PBX1 fusion gene in Chinese children with acute lymphoblastic leukemia by using a modified ALL-BFM-95 protocol.
|
25551271 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Investigation for TCF3(E2A)-PBX1 rearrangements may be useful in BCL6-positive B-lymphoblastic leukemia.
|
25780007 |
2015 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study reviewed the clinical characteristics of 112 pediatric B-cell precursor acute lymphoblastic leukemia (BCP-ALL) patients with TCF3-PBX1 fusion treated according to the Japan Association of Childhood Leukemia Study (JACLS) ALL02 protocol (n = 82) and Children's Cancer and Leukemia Study Group (CCLSG) ALL 2004 protocol (n = 30).
|
24578304 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
For example, whereas the E2A portion of the E2A-Pbx1 leukemia fusion protein mediates robust transcriptional activation in t(1;19) acute lymphoblastic leukemia, the transcriptional activity of wild-type E2A is silenced by high levels of corepressors, such as the AML1-ETO fusion protein in t(8;21) acute myeloid leukemia and ETO-2 in hematopoietic cells.
|
24064250 |
2014 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GCN5 acetylates and regulates the stability of the oncoprotein E2A-PBX1 in acute lymphoblastic leukemia.
|
23044487 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
E2A-PBX1 fusion gene caused by t(1;19)(q23;p13), has been well characterized in acute lymphoid leukemia (ALL).
|
23688269 |
2013 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
E2A, 1 of 3 E-protein-encoding genes, is implicated in the induction of acute lymphoblastic leukemia through its involvement in the chromosomal translocation 1;19 and consequent expression of the E2A-PBX1 oncoprotein.
|
22972988 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In E2A-PBX1-positive B-ALLs, aberrant DNA methylation patterning was strongly associated with direct fusion protein binding as shown by the E2A-PBX1 chromatin immunoprecipitation (ChIP) sequencing (ChIP-seq), suggesting that E2A-PBX1 fusion protein directly remodels the epigenome to impose an aggressive B-ALL phenotype.
|
23107779 |
2012 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GAS6/Mer axis regulates the homing and survival of the E2A/PBX1-positive B-cell precursor acute lymphoblastic leukemia in the bone marrow niche.
|
19922767 |
2010 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PAX5 mutations occur frequently in adult B-cell progenitor acute lymphoblastic leukemia and PAX5 haploinsufficiency is associated with BCR-ABL1 and TCF3-PBX1 fusion genes: a GRAALL study.
|
19587702 |
2009 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Both genes are known to be targeted also by other neoplasia-specific translocations, PBX1 in acute lymphoblastic leukemia and EWSR1 in several solid tumors, most of which are malignant.
|
18383210 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
BCR-ABL, ETV6-RUNX1 and E2A-PBX1: prevalence of the most common acute lymphoblastic leukemia fusion genes in Mexican patients.
|
18455790 |
2008 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Incidence and outcome of TCF3-PBX1-positive acute lymphoblastic leukemia in Austrian children.
|
18024406 |
2007 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ZAP-70 expression in acute lymphoblastic leukemia: association with the E2A/PBX1 rearrangement and the pre-B stage of differentiation and prognostic implications.
|
16160012 |
2006 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
[Detection of fusion genes resulting from chromosome abnormalities in childhood acute lymphoblastic leukemia].
|
16215946 |
2005 |
|
Precursor Cell Lymphoblastic Leukemia Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The t(1;19) translocation yields a fusion between E2A and PBX1 genes and occurs in 5% of acute lymphoblastic leukemia in children and adults.
|
12415113 |
2002 |