PBX1, PBX homeobox 1, 5087

N. diseases: 167; N. variants: 14
Disease: Malignant neoplasm of ovary ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE We further demonstrated that a STAT3/JAK2 inhibitor could potently sensitize platinum-resistant cells to carboplatin and suppress their growth in vivo Our findings offer a mechanistic rationale to target the PBX1/STAT3 axis to antagonize a key mechanism of chemoresistance in ovarian cancers and possibly other human cancers. 27590741 2016
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE These results demonstrate that MEOX1 is a critical target gene and cofactor of PBX1 in ovarian cancers. 22567123 2012
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.030 Biomarker disease BEFREE Identification of Pbx1, a potential oncogene, as a Notch3 target gene in ovarian cancer. 18974129 2008