PBX1, PBX homeobox 1, 5087

N. diseases: 167; N. variants: 14
Disease: Burkitt Leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4721444
Disease: Burkitt Leukemia
Burkitt Leukemia 		0.310 Biomarker disease CTD_human B-cell development fails in the absence of the Pbx1 proto-oncogene. 17244677 2007
CUI: C4721444
Disease: Burkitt Leukemia
Burkitt Leukemia 		0.310 GeneticVariation disease BEFREE Approximately 6% of paediatric patients with precursor B-cell acute lymphoblastic leukaemia (B-ALL) harbour a rearrangement involving the gene regions of PBX1 (1q23) and E2A (19p13.3) which is visualized cytogenetically either as a der(19)t(1;19)(q23;p13.3) or the less common balanced t(1;19)(q23;p13.3). 15801954 2005
CUI: C4721444
Disease: Burkitt Leukemia
Burkitt Leukemia 		0.310 Biomarker disease CTD_human Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. 1967982 1990