|
Burkitt Lymphoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
B-cell development fails in the absence of the Pbx1 proto-oncogene.
|
17244677 |
2007 |
|
Burkitt Lymphoma
|
0.500 |
Biomarker
|
disease |
CTD_human |
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor.
|
1967982 |
1990 |
|
Burkitt Lymphoma
|
0.500 |
FusionGene
|
disease |
ORPHANET |
|
|
|
|
CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
PBX1 is an essential developmental transcription factor, mutations in which have recently been associated with CAKUTHED syndrome, characterised by multiple congenital defects including congenital heart disease.
|
31625560 |
2019 |
|
CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY
|
0.410 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
PBX1 haploinsufficiency leads to syndromic congenital anomalies of the kidney and urinary tract (CAKUT) in humans.
|
28270404 |
2017 |
|
CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY
|
0.410 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
CONGENITAL ANOMALIES OF KIDNEY AND URINARY TRACT SYNDROME WITH OR WITHOUT HEARING LOSS, ABNORMAL EARS, OR DEVELOPMENTAL DELAY
|
0.410 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Flow cytometric predictive scoring systems for common fusions ETV6/RUNX1, BCR/ABL1, TCF3/PBX1 and rearrangements of the KMT2A gene, proposed for the initial cytogenetic approach in cases of B-acute lymphoblastic leukemia.
|
30730614 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the binding of the E2A-PBX1 chimeric protein to the <i>BAFFR</i> promoter suggests that the transcriptional activator promotes the increase in <i>BAFFR</i> expression observed in about 50% of pre-B-ALL patients carrying the <i>t</i><sub>(1, 19)</sub> translocation.
|
31380267 |
2019 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The prognostic role of E2A-PBX1 expression detected by real-time quantitative reverse transcriptase polymerase chain reaction (RQ-PCR) in B cell acute lymphoblastic leukemia after allogeneic hematopoietic stem cell transplantation.
|
29705861 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
NGS-based methylation profiling differentiates TCF3-HLF and TCF3-PBX1 positive B-cell acute lymphoblastic leukemia.
|
29334255 |
2018 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The outcomes of patients with t(1;19)/TCF3-PBX1 were compared to that of patients with other subtypes of B-precursor ALL (B-ALL).
|
28436581 |
2017 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Additional experiments revealed that uc.38 negatively regulated the expression of the pre-B-cell leukaemia homeobox 1 (PBX1) protein and subsequently affected the expression of Bcl-2 family members, ultimately inducing breast cancer cell apoptosis.
|
29312798 |
2017 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In this study, we describe remodeling of signaling networks by E2A-PBX1 in pre-B-ALL, which results in hyperactivation of the key oncogenic effector enzyme PLCγ2.
|
27758892 |
2016 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
When intensive chemotherapy was used, the TCF3-PBX1 was associated with a favorable outcome in childhood pre-B ALL.
|
25551271 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Autophagy collaborates with ubiquitination to downregulate oncoprotein E2A/Pbx1 in B-cell acute lymphoblastic leukemia.
|
25615280 |
2015 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Rational design of an immunoconjugate for selective knock-down of leukemia-specific E2A-PBX1 fusion gene expression in human Pre-B leukemia.
|
22990208 |
2013 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
In particular, E2A-PBX1 silencing affected the EB-1 gene, which encodes for a protein that could contribute to the transformed phenotype of pre-B ALL.
|
16769578 |
2006 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
Allogeneic stem cell transplantation improves the outcome of adults with t(1;19)/E2A-PBX1 and t(4;11)/MLL-AF4 positive B-cell acute lymphoblastic leukemia: results of the prospective multicenter LALA-94 study.
|
17039234 |
2006 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
The t(1;19) translocation of pre-B cell acute lymphocytic leukemia (ALL) produces E2a-Pbx1, a chimeric oncoprotein containing the transactivation domains of E2a joined to the homeodomain protein, Pbx1.
|
10490826 |
1999 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chimeric E2A-PBX1 transcripts generated by the t(1;19) were found in only two of the 87 B-precursor ALL analyzed.
|
9172811 |
1996 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
Biomarker
|
disease |
BEFREE |
To address the utility of RT-PCR analysis towards the detection of mRNA associated with specific gene alterations in such specimens, a primer pair for amplification of the E2A-PBX1 fusion cDNA was used in PCRs of RT cDNAs for each of the 23 specimens, three of which were pre-B-cell acute lymphoblastic leukemias known to have the t(1;19) karyotype alteration resulting in the fusion of the E2A and PBX1 genes.
|
8483891 |
1993 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice.
|
8093327 |
1993 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Here we described a new fusion site of the E2A and PBX1 genes, which was detected in the leukemic blasts of a child with t(1;19) pre-B ALL using the reverse transcriptase polymerase chain reaction and direct sequencing.
|
8103813 |
1993 |
|
Precursor B-cell lymphoblastic leukemia
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
These findings are at variance with a recent report in which expression of the E2A/PBX1 message was linked exclusively to a subset of patients who displayed a cig+ pre-B-cell precursor phenotype of ALL.
|
8255105 |
1993 |