ACOX1, acyl-CoA oxidase 1, 51

N. diseases: 95; N. variants: 12
Disease: Hepatocarcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.020 Biomarker disease BEFREE Peroxisomal ACOX1 (acyl-CoA oxidase 1) is the first and rate-limiting enzyme in fatty acid β-oxidation and a major producer of H<sub>2</sub>O<sub>2</sub> ACOX1 dysfunction is linked to peroxisomal disorders and hepatocarcinogenesis. 29491006 2018
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.020 Biomarker disease BEFREE Taken together, our data indicate that progressive PPARα- and p8-mediated ER stress contribute to the hepatocarcinogenesis in ACOX1(-/-) mice. 21801867 2011