|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Xenografts of MM tumors treated with this combination had marked increases in phospho-c-Jun-NH(2)-kinase (JNK)-positive cells and apoptosis, and corresponding reductions in tumor burden, tumor vasculature, and the expression of proliferating cell nuclear antigen and the proangiogenic cytokine vascular endothelial growth factor.
|
18559525 |
2008 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The highest levels of PCNA were observed in advanced stage tumors with an amplified N-myc gene.
|
8093685 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The hypothesis that alterations in tumor suppressor gene expression was related to cell proliferation was tested by simultaneously demonstrating the expression of the proliferating cell nuclear antigen in methacarn-fixed, paraffin-embedded tissue sections of the same tumors.
|
8552572 |
1995 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
MicroRNA-204 inhibits the proliferation, migration and invasion of human lung cancer cells by targeting PCNA-1 and inhibits tumor growth in vivo.
|
30628638 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
POLQ expression provides thus an additional indicator for the survival outcome of patients with high Cyclin E tumor expression or high number of positive lymph nodes.
|
20624954 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These data show no significant correlation coefficient between Ki-67 or PCNA TPIs and SPFs derived from FCM analysis; however, the DNA diploid tumor subset categorized as having a greater than median SPF value had a significantly higher mean Ki-67 but not PCNA proliferation index.
|
8104388 |
1993 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In xenografts, p-NO-ASA inhibited tumor growth by inhibiting proliferation (PCNA and tumor volume), inducing apoptosis (TUNEL positive cells) and reducing NF-κB expression.
|
26184135 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that RXL motif-based inhibitors will provide selective antiproliferative agents with in vivo efficacy in tumors with deregulated Rb/cyclin D pathways.
|
12615717 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cyclin E protein accumulation was found in 48 different tumour types.
|
12845634 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Increasing evidence demonstrated that cyclin‑dependent kinase regulatory subunit 1B (CKS1B) may be involved in the pathogenesis of various tumor types, including multiple myeloma and breast cancer.
|
31115482 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
No correlation was found between the severity of PCNA expression and tumor front grading.
|
12740649 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, DPF significantly decreased the expression of cell proliferation markers PCNA and ki67 in tumors.
|
19064947 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A. camphorata treatment also inhibited proliferation (cyclin D1 and PCNA) and induced apoptosis (Bcl-2 and TUNEL) when the tumor tissue sections were examined histologically and immunohistochemically.
|
18550246 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A significant difference was found between the PCNA index in p53 positive and p53 negative tumors while the mean PCNA index for the tumors with p53 mutations was not significantly different from the tumors without mutations.
|
9568083 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Knowledge of the percentage of PCNA-positive cells could be especially helpful in deciding whether to treat patients with localized disease further because adjuvant chemotherapy affects mainly dividing cells and should, therefore, be more successful in tumors with high proliferative activity.
|
8095852 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The intestinal tumor burden and tumor expression of β-catenin and PCNA was compared in Cables1(+/+)Apc(Min/+) and Cables1(-/-)Apc(Min/+) mice.
|
23792637 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Herein, we report that metformin significantly inhibited human epidermoid A431 tumor xenograft growth in nu/nu mice, which was associated with a significant reduction in proliferative biomarkers PCNA and cyclins D1/B1.
|
22540890 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
KLF4 and PCNA identify stages of tumor initiation in a conditional model of cutaneous squamous epithelial neoplasia.
|
16357510 |
2005 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Overall, the tumor volume and the PCNA LI% within live tumor areas were reduced by 83% and 99%, respectively, in all TAM-treated groups when compared to the untreated control group.
|
23634930 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Xenografting control cells devoid of cav-1 in nude mice induced development of bigger tumors expressing higher levels of proliferating cell nuclear antigen as compared to mice injected with cells expressing the highest cav-1 levels.
|
22674854 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Dysregulation of one of the three D-cyclin genes has been observed in virtually all multiple myeloma tumors.
|
26341922 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tumors with higher PCNA index (> or = 31.5%) and negative p53 protein expression appeared to respond better than other tumors, but the difference was not statistically significant.
|
9159335 |
1997 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The expression of cancer-related genes β-catenin, CD44, MMP-2, ICAM-1, and PCNA in the tumor was analyzed by RT-PCR, western blotting and immunohistochemistry in both sublines.
|
29848673 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results showed that NP-Pt treatment of U87 and U118 glioma cells decreased the level of DNA synthesis and the migration of cancer cells but also downregulated the level of PCNA protein expression in tumour tissue.
|
28562655 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
As<sub>2</sub>O<sub>3</sub>-NPs inhibited tumor growth more strongly than As<sub>2</sub>O<sub>3</sub> or control, a finding likely attributed to the downregulation of PCNA and DNMT-related proteins and the upregulation of GSDME-N.
|
31637008 |
2019 |