|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Resected hepatoma tissue was stained immunohistochemically with antibodies for proliferating cell nuclear antigen (also called cyclin), a marker of cell proliferation.
|
7927250 |
1994 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In addition, we inhibited DNMT1 using siRNA in the SMMC-7721 HCC cell line and found depletion of DNMT1 suppressed cells growth independent of expression of proliferating cell nuclear antigen (PCNA), even in HCC cell lines where DNMT1 was stably decreased.
|
19399937 |
2009 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
LHGDN |
The aim of the study was to analyze to what extent the presence of DNA-bound PCNA and p21 correlates with cell proliferation and DNA-repair in hepatocellular carcinoma (HCC).
|
14642618 |
2003 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
This study analyzed the correlation of aPKC-iota with clinicopathology in hepatocarcinoma and Cyclin E and investigated molecular mechanisms of invasion and metastasis of hepatocellular carcinoma.
|
19101699 |
2009 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The expression of NET-1 in HCC tissues was positively correlated with PCNA.
|
18214716 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The serine/threonine-protein kinase PFTAIRE 1 (PFTK1) is a member of the cyclin‑dependent kinase family that is highly expressed in several malignant tumors, including hepatocellular carcinoma, esophageal, breast and gastric cancers, and glioma.
|
28498444 |
2017 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The positive rate of PCNA in HCC was significantly higher compared to control (P<0.0001) and non-tumor liver tissues (P<0.0001).
|
23292006 |
2013 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
A positive correlation was established between the levels of AIB1 protein and PCNA protein in HCC, suggesting that AIB1 may contribute to HCC cell proliferation.
|
20305690 |
2010 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
These findings suggested that a miR-199/XBP1/cyclin D axis may serve an important role in the pathogenesis of HCC.
|
30405792 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Sixty-two HCC samples were recruited for evaluation of Id-1 and proliferating cell nuclear antigen (PCNA) protein expression.
|
12949053 |
2003 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
In vivo, hepatocytes isolated from HCC tumor tissue and matching paracancerous tissue in DEN-treated CCR10 KO mice showed significantly lower Akt phosphorylation and PCNA expression relative to WT hepatocytes.
|
29445190 |
2018 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The pre-S(2) mutant LHBS-induced pro-oncogenic effects: increased cell proliferation, nuclear/cytoplasmic ratio and proliferating cell nuclear antigen expression, were all greatly ameliorated after SAHA treatments, which suggested SAHA as a promising chemopreventive agent for the pre-S(2) mutant oncoprotein-induced HCC.
|
23172669 |
2013 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
Among the various types of cell-cycle regulators, p16 and p27 are frequently inactivated in HCC and are considered to be potent tumor suppressors. p16, a G1-specific cell-cycle inhibitor that prevents the association of cyclindependent kinase (CDK) 4 and CDK6 with cyclin D1, is frequently inactivated in HCC via CpG methylation of its promoter region. p16 may be involved in the early steps of hepatocarcinogenesis, since p16 gene methylation has been detected in subsets of pre-neoplastic liver cirrhosis patients. p27, a negative regulator of the G1-S phase transition through inhibition of the kinase activities of Cdk2/cyclin A and Cdk2/cyclin E complexes, is now considered to be an adverse prognostic factor in HCC.
|
18350604 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Taken together, cells treated with oxaliplatin+ ginsenoside enhanced the anti-tumor effect and may inhibit the proliferation and promoted apoptosis of hepatocellular carcinoma via regulating the expression of PCNA and cyclin D1.
|
30930425 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We also show that RMP depletion induced the G(2) arrest of HCC cells characterized by the decreased expression of Cdk1 and Cyclin B. Tumor formation assays further confirmed the in vivo requirement of RMP during HCC growth.
|
21310960 |
2011 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
In 6 of 12 HCCs and in cell lines, we found three major PCNA acidic forms, corresponding to monomers, probably dimers and trimers, and a basic isoform.
|
18521065 |
2008 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
PCNA was co-localized with active caspase 3 protein expression in HBx zebrafish liver samples and human HBV positive HCC samples by double fluorescence immunostaining.
|
23499292 |
2013 |
|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
BEFREE |
The expressions of liver X receptor (LXR)-α, glucose transporter (Glut)-1, proliferating cell nuclear antigen (PCNA), and matrix metalloproteinase (MMP)-9 were analyzed from HCC public database (NCBI PubMed database).
|
30817182 |
2019 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
Consistent with these results, the expression of SRC-1 was positively correlated with PCNA expression in human HCC specimens, and the expression levels of c-Myc in SRC-1-positive HCC specimens were higher than in SRC-1-negative HCC specimens.
|
26082485 |
2015 |
|
Liver carcinoma
|
0.300 |
AlteredExpression
|
disease |
LHGDN |
There is a marked loss or absence of p57(kip2) expression and high expression of PCNA in HCC, which are involved in carcinogenesis and development of HCC.
|
15754413 |
2005 |