ANGPTL4, angiopoietin like 4, 51129

N. diseases: 21; N. variants: 5
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.500 Biomarker disease CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400 2016
CUI: C0028754
Disease: Obesity
Obesity 		0.400 Therapeutic disease CTD_human We show here that the purified FLD of Angptl4 is sufficient to stimulate lipolysis in mouse primary adipocytes and that increasing circulating FLD levels in mice through adenovirus-mediated overexpression (Ad-FLD) not only induces WAT lipolysis <i>in vivo</i> but also reduces diet-induced obesity without affecting LPL activity. 28842503 2017
CUI: C0010054
Disease: Coronary Arteriosclerosis
Coronary Arteriosclerosis 		0.400 Biomarker disease CTD_human Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease. 27135400 2016
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Therapeutic phenotype CTD_human Furthermore, melanoma B16F0 cells injected into the retro-orbital sinus also metastasized less efficiently in mice expressing ANGPTL4. 17130448 2006
CUI: C0020557
Disease: Hypertriglyceridemia
Hypertriglyceridemia 		0.350 Biomarker phenotype CTD_human The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure. 28842503 2017
CUI: C0242339
Disease: Dyslipidemias
Dyslipidemias 		0.350 Biomarker group CTD_human Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. 17322881 2007
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.340 Biomarker disease CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.330 Biomarker disease CTD_human Also in humans, ANGPTL4 was unmethylated and expressed in normal mammary epithelial cells, but was methylated in 11 of 91 (12%) primary breast cancers. 21489049 2011
CUI: C0015695
Disease: Fatty Liver
Fatty Liver 		0.320 Biomarker disease CTD_human The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure. 28842503 2017
CUI: C2711227
Disease: Steatohepatitis
Steatohepatitis 		0.320 Biomarker disease CTD_human The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure. 28842503 2017
CUI: C0007097
Disease: Carcinoma
Carcinoma 		0.310 Biomarker group CTD_human This is the first study to identify genes aberrantly methylated in rat mammary carcinomas, and Angptl4 is a novel methylation-silenced gene both in rat and human mammary carcinomas. 21489049 2011
CUI: C1458155
Disease: Mammary Neoplasms
Mammary Neoplasms 		0.310 Biomarker group CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C0205696
Disease: Anaplastic carcinoma
Anaplastic carcinoma 		0.300 Biomarker disease CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C0205697
Disease: Carcinoma, Spindle-Cell
Carcinoma, Spindle-Cell 		0.300 Biomarker disease CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C0205698
Disease: Undifferentiated carcinoma
Undifferentiated carcinoma 		0.300 Biomarker disease CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C0205699
Disease: Carcinomatosis
Carcinomatosis 		0.300 Biomarker phenotype CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C1257931
Disease: Mammary Neoplasms, Human
Mammary Neoplasms, Human 		0.300 Biomarker disease CTD_human Methylation silencing of angiopoietin-like 4 in rat and human mammary carcinomas. 21489049 2011
CUI: C4704874
Disease: Mammary Carcinoma, Human
Mammary Carcinoma, Human 		0.300 Biomarker disease CTD_human This is the first study to identify genes aberrantly methylated in rat mammary carcinomas, and Angptl4 is a novel methylation-silenced gene both in rat and human mammary carcinomas. 21489049 2011
CUI: C0598784
Disease: Dyslipoproteinemias
Dyslipoproteinemias 		0.300 Biomarker phenotype CTD_human Population-based resequencing of ANGPTL4 uncovers variations that reduce triglycerides and increase HDL. 17322881 2007
CUI: C0024232
Disease: Lymphatic Metastasis
Lymphatic Metastasis 		0.300 Therapeutic disease CTD_human Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. 17130448 2006
CUI: C0027626
Disease: Neoplasm Invasiveness
Neoplasm Invasiveness 		0.300 Therapeutic phenotype CTD_human Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness. 17130448 2006