Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT Functional assessment of the mutational effects of human IRAK4 and MyD88 genes. 24316379 2014
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 Biomarker disease BEFREE To better understand the clinical significance of IRAK4 deficiency we examined the impact of IRAK4 on bacterial recognition in human monocytes. 23519847 2013
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT We documented the clinical features and outcome of 48 patients with IRAK-4 deficiency and 12 patients with MyD88 deficiency, from 37 kindreds in 15 countries.The clinical features of IRAK-4 and MyD88 deficiency were indistinguishable. 21057262 2010
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT Impaired neutrophil migration and phagocytosis in IRAK-4 deficiency. 19663824 2009
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway. 17878374 2007
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT Pyogenic bacterial infections in humans with IRAK-4 deficiency. 12637671 2003
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GeneticVariation disease UNIPROT Distinct mutations in IRAK-4 confer hyporesponsiveness to lipopolysaccharide and interleukin-1 in a patient with recurrent bacterial infections. 12925671 2003
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 Biomarker disease CTD_human
CUI: C1843256
Disease: IRAK4 Deficiency
IRAK4 Deficiency 		0.610 GermlineCausalMutation disease ORPHANET
CUI: C1835828
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1
Invasive Pneumococcal Disease, Recurrent Isolated, 1 		0.500 Biomarker disease GENOMICS_ENGLAND TLR9 activation induces normal neutrophil responses in a child with IRAK-4 deficiency: involvement of the direct PI3K pathway. 17878374 2007
CUI: C1835828
Disease: Invasive Pneumococcal Disease, Recurrent Isolated, 1
Invasive Pneumococcal Disease, Recurrent Isolated, 1 		0.500 Biomarker disease CTD_human
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.340 Biomarker disease BEFREE The IRAK4i I92 exhibits a broader inhibitory effect than HCQ on proinflammatory pathways triggered by RNA-IC, suggesting IRAK4 inhibition as a therapeutic option in SLE. 30355354 2018
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.340 Biomarker disease CTD_human Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. 28003376 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.340 AlteredExpression disease BEFREE Thus, IRAK4 kinase activity contributes to murine lupus and could represent a new therapeutic target. 28295231 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.340 Biomarker disease BEFREE Lastly, BMS-986126 inhibited TLR7- and TLR9-dependent responses using cells derived from lupus patients, suggesting that inhibition of IRAK4 has the potential for therapeutic benefit in treating lupus. 28003376 2017
CUI: C0024141
Disease: Lupus Erythematosus, Systemic
Lupus Erythematosus, Systemic 		0.340 GeneticVariation disease BEFREE Examples include variants of TLR4 in sepsis, malaria, inflammatory bowel disease and atherosclerosis; variants in TLR2 in tuberculosis and asthma; a variant in Mal (a key signal for TLR2 and TLR4) in malaria, tuberculosis and systemic lupus erythematosus; and variants in the kinase IRAK4 in pyogenic infections. 20375592 2009
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.310 Biomarker disease CTD_human Although the single-nucleotide polymorphisms in IRAK1 and IRAK4 alone were not significantly associated with prostate cancer risk, one single-nucleotide polymorphism in IRAK4, when combined with the high-risk genotype at TLR6-1-10, conferred a significant excess risk of prostate cancer. 16537705 2006
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.310 GeneticVariation disease BEFREE Although the single-nucleotide polymorphisms in IRAK1 and IRAK4 alone were not significantly associated with prostate cancer risk, one single-nucleotide polymorphism in IRAK4, when combined with the high-risk genotype at TLR6-1-10, conferred a significant excess risk of prostate cancer. 16537705 2006
CUI: C0242380
Disease: Libman-Sacks Disease
Libman-Sacks Disease 		0.300 Biomarker disease CTD_human Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. 28003376 2017
CUI: C0178540
Disease: Cerebral Hypoxia-Ischemia
Cerebral Hypoxia-Ischemia 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011
CUI: C0752304
Disease: Hypoxic-Ischemic Encephalopathy
Hypoxic-Ischemic Encephalopathy 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011
CUI: C0752305
Disease: Anoxic-Ischemic Encephalopathy
Anoxic-Ischemic Encephalopathy 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011
CUI: C0752306
Disease: Anoxia-Ischemia, Brain
Anoxia-Ischemia, Brain 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011
CUI: C0752307
Disease: Anoxia-Ischemia, Cerebral
Anoxia-Ischemia, Cerebral 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.300 Biomarker disease CTD_human Interleukin-1 receptor associated kinases-1/4 inhibition protects against acute hypoxia/ischemia-induced neuronal injury in vivo and in vitro. 21925238 2011