|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared with the S group, the expression level of LC3-II in the infarcted peripheral area was significantly increased and that of p62 was significantly increased in the AMI group.
|
28925470 |
2017 |
|
Acute pancreatitis
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
After over-expressing miR-148a, Western blot and immunohistochemical method were used to confirm the reduction of autophagosomes and autolysosomes, blockade of the levels of p-STAT3, LC3-II, ATG7, ATG4c, Beclin1 and the increased p62 expression in AP.
|
31122822 |
2019 |
|
Acute pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Compared to control group, the number of autophagic vacuoles and expressions of autophagy-related markers including Beclin-1, p62 and LC3-II were increased in AP models, In contrast, the degree of inflammation and levels of inflammatory cytokines in AP models were reduced after resolvin D1 treatment.
|
29974378 |
2018 |
|
Acute Promyelocytic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
MAT also promoted the autophagy in NB4-LR1 cells, with an increase in microtubule-associated protein 1 light chain3 (LC3)-II and LC3-II/LC3-I ratio and exhaustion of P62.
|
30114705 |
2018 |
|
Acute-On-Chronic Liver Failure
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
<b>Results:</b> Compared with the normal liver tissue, the expressions of Mfn2, Atg5, Beclin1, and LC3-II/I were significantly decreased and the expression of P62 was much higher in patients with ACLF.
|
31231215 |
2019 |
|
Acute-On-Chronic Liver Failure
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Mfn2 improved the expressions of LC3-II, Atg5 and Bcl-2 and down-regulated the expression of P62 and Bax in ACLF.
|
31557386 |
2019 |
|
Adenocarcinoma
|
0.040 |
Biomarker
|
group |
BEFREE |
LC3B and p62 could be used as prognostic biomarkers and potential therapeutic targets for gastric adenocarcinomas.
|
31810936 |
2019 |
|
Adenocarcinoma
|
0.040 |
GeneticVariation
|
group |
BEFREE |
Moreover, p62 and VPRBP were associated with poor prognosis in lung ADC (adenocarcinoma) (p62, P=0.019; VPRBP, P=0.005).
|
22963397 |
2013 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
|
29897944 |
2018 |
|
Adenocarcinoma
|
0.040 |
AlteredExpression
|
group |
BEFREE |
Correction: A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.
|
31665193 |
2019 |
|
Adenocarcinoma of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Distinct prognostic value of dynactin subunit 4 (DCTN4) and diagnostic value of DCTN1, DCTN2, and DCTN4 in colon adenocarcinoma.
|
30510450 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.
|
28604730 |
2017 |
|
Adenocarcinoma of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Cytosolic overexpression of p62 is a novel immunohistochemical characteristic in prostatic adenocarcinoma and high-grade PIN, suggesting that p62 might be a novel marker for prostatic malignancy.
|
16405664 |
2006 |
|
Adrenoleukodystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found impaired autophagy both in ALD and alcoholic hepatitis (AH) mouse models and human livers with ALD as indicated by increased hepatic p62 and LC3-II levels.
|
31090940 |
2019 |
|
Adult Glioblastoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The effect of extracellular high-mobility group box 1 (HMGB1) protein on glioblastoma (GBM) progression is still controversial. p62 is overexpressed in glioma cells, and has been associated with the malignant features and poor prognosis of GBM patients.
|
31037147 |
2019 |
|
Adult Glioblastoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
The autophagy-associated factors DRAM1 and p62 regulate cell migration and invasion in glioblastoma stem cells.
|
22525272 |
2013 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Evidence has shown that p62 is upregulated in different cancers and promotes tumour growth, such as in liver cancer and lung cancer.
|
30793399 |
2019 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Aberrant expression of fetal RNA-binding protein p62 in liver cancer and liver cirrhosis.
|
11549587 |
2001 |
|
Adult type dermatomyositis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The prominent p62 immunohistochemical positivity and pattern diagnostically distinguish s-IBM from polymyositis and dermatomyositis.
|
19557423 |
2009 |
|
Adult-Onset Still Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated autophagosome formation and p62 levels suggest impaired autophagic flux in AOSD.
|
29416600 |
2018 |
|
Age related macular degeneration
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Our study supports HuR's role as an upstream regulator of p62 expression in ARPE-19 cells, helps to understand better the early events in response to a proautophagy stimulus, and suggests that modulation of the autophagy-regulating kinases as potential therapeutic targets for AMD may be relevant.
|
29576851 |
2018 |
|
Age related macular degeneration
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Autophagic flux was also reduced in AMD RPE as compared with normal RPE, as shown by inability of AMD RPE to downregulate p62 levels during starvation.
|
28055007 |
2017 |
|
Alzheimer's Disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the levels of p62 also significantly decreased, and the cathepsin D levels increased, accompanied by increased turnover of Aβ and APP in Se-yeast-treated AD mice.
|
30043821 |
2018 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
p62, also known as sequestosome1, is a shuttle protein transporting polyubiquitinated proteins for both the proteasomal and lysosomal degradation. p62 is an integral component of inclusions in brains of various neurodegenerative disorders, including Alzheimer disease (AD) neurofibrillary tangles (NFTs) and Lewy bodies in Parkinson disease.
|
19557423 |
2009 |
|
Alzheimer's Disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mutant ubiquitin and p62 immunoreactivity in cases of combined multiple system atrophy and Alzheimer's disease.
|
17237936 |
2007 |