|
Polycystic Ovary Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Similarly, SOR also enhanced the expression of LC3-II and Caspase-3 in PCOS while substantially reducing the level of mTORC2 and P62.
|
31256441 |
2020 |
|
Intervertebral Disc Degeneration
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, p62 increased progressively with increasing disc degeneration grade.
|
31802633 |
2020 |
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identify that TBK1 phosphorylates p62/SQSTM1 on Ser366 which is essential for p62 stability and kidney cancer cell proliferation.
|
31810986 |
2020 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We identify that TBK1 phosphorylates p62/SQSTM1 on Ser366 which is essential for p62 stability and kidney cancer cell proliferation.
|
31810986 |
2020 |
|
Malignant neoplasm of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our results suggest that i) cytoplasmic p62 and PTOV1 can be considered prognostic markers in laryngeal cancer, ii) the acquisition of resistance seems to be related to PTOV1 and autophagy-related protein overexpression, iii) by increasing autophagy, PTOV1 might contribute to resistance in this model and iv) the expression of autophagy-related proteins could classify a subgroup of laryngeal cancer patients who will benefit from a therapy based upon autophagy inhibition.
|
31050705 |
2019 |
|
Down Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
This conclusion was further supported by the observation that over-expression of either STX17 or VAMP8 in DS fibroblasts restored autophagic degradation and reversed p62 accumulation.
|
31714914 |
2019 |
|
Hepatitis A
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Results showed that DHAV infection increased the expression level of LC3-II and interdicted the degradation of p62.
|
30658794 |
2019 |
|
Hepatitis, Alcoholic
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found impaired autophagy both in ALD and alcoholic hepatitis (AH) mouse models and human livers with ALD as indicated by increased hepatic p62 and LC3-II levels.
|
31090940 |
2019 |
|
leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of p62 impaired expansion and colony-forming ability of leukemia cells and prolonged latency of leukemia development in mice.
|
30498063 |
2019 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High p62 expression was associated with poor prognosis in human AML.
|
30498063 |
2019 |
|
Leukoencephalopathy, Progressive Multifocal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Mechanistically, XPO1 inhibition induces relocalization of autophagy adaptor protein p62 (SQSTM1), recruiting p53 for activation in PML nuclear bodies.
|
31088931 |
2019 |
|
Melanocytic nevus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Immunohistochemistry for CD271 and p62 was performed on human naevi and primary malignant melanoma tumours.
|
30339727 |
2019 |
|
Degenerative polyarthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In addition, the effect of intra-articularly injected WY14643 on articular cartilage in a mouse OA model established by the destabilization of the medial meniscus was assessed using the Osteoarthritis Research Society International (OARSI) histopathology assessment system, along with the detection of Aggrecan, ADAMTS5, LC3B and P62 protein levels using immunohistochemistry assay.
|
30729704 |
2019 |
|
Osteopenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Interestingly, p62 deficiency provoked accelerated osteopenia and impaired niche operational activities within the bone marrow.
|
30740681 |
2019 |
|
Periodontitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Intriguingly, autophagy markers LC3B and P62 were upregulated in the pulp obtained from teeth with periodontitis.
|
31161648 |
2019 |
|
Gastrointestinal tract vascular insufficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Chiu's score, intestinal mucosal wet-to-dry ratio, lactic acid level, malondialdehyde level, autophagosomes, and LC3-II/LC3-I were significantly increased, and superoxide dismutase level and expression of p62 were significantly decreased in intestinal mucosa after intestinal ischemia/reperfusion.
|
31277013 |
2019 |
|
Adrenoleukodystrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found impaired autophagy both in ALD and alcoholic hepatitis (AH) mouse models and human livers with ALD as indicated by increased hepatic p62 and LC3-II levels.
|
31090940 |
2019 |
|
Liver Failure, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ACY1215 could induce autophagy in ALF mice and cell model group accompanied with an increase in expression of LC3-II and beclin-1 proteins and down-regulation of p62 protein.
|
31634464 |
2019 |
|
Basophilic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transmission electron microscopy showed p62 within extracellular vesicles of antigen-stimulated rat basophilic leukemia cells (RBL2H3).
|
31024564 |
2019 |
|
Decreased drug resistance
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
In addition, it was identified that CLDN1 silencing decreased drug resistance by inhibiting autophagy, which was associated with a decrease in the ratio of microtubule-associated protein 1A/1B-light chain 3 (LC3)-II/LC3-I and upregulation of P62.
|
31788043 |
2019 |
|
Carcinoma of larynx
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our results suggest that i) cytoplasmic p62 and PTOV1 can be considered prognostic markers in laryngeal cancer, ii) the acquisition of resistance seems to be related to PTOV1 and autophagy-related protein overexpression, iii) by increasing autophagy, PTOV1 might contribute to resistance in this model and iv) the expression of autophagy-related proteins could classify a subgroup of laryngeal cancer patients who will benefit from a therapy based upon autophagy inhibition.
|
31050705 |
2019 |
|
Diabetic peripheral neuropathy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings demonstrate that hyperglycemia inhibits LC3-II/LC3-I in an HDAC1-Atg3-dependent manner and decreases P62 expression in an HDAC-independent manner <i>via</i> the JAK-STAT3 signaling pathway in the Schwann cells of DPN.-Du, W., Wang, N., Li, F. Jia, K., An, J., Liu, Y., Wang, Y., Zhu, L., Zhao, S. Hao, J. STAT3 phosphorylation mediates high glucose-impaired cell autophagy in an HDAC1-dependent and -independent manner in Schwann cells of diabetic peripheral neuropathy.
|
30913399 |
2019 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of the p62 sequestosome 1 (P62/SQSTM1) protein, p-ERK/ERK, phospho-mammalian target of rapamycin (p-mTOR) and phospho-p70S6 were increased in SPC-HIBI group.
|
30460641 |
2019 |
|
Sarcopenia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Studies in experimental animals and in patients demonstrate that ammonia is directly implicated in the pathogenesis of sarcopenia in cirrhosis via mechanisms involving increased expression of myostatin and of autophagy markers such as LC3 lipidation and p62 leading to muscle dysmetabolism and sarcopenia.
|
31183339 |
2019 |
|
Liver regeneration disorder
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
These findings suggest that accumulation of p62 due to loss of Ctsl plays an important role in liver regeneration through activation of Nrf2-Notch1 signaling.
|
30797017 |
2019 |