DCTN4, dynactin subunit 4, 51164

N. diseases: 253; N. variants: 4
Disease: Age related macular degeneration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 AlteredExpression disease BEFREE Our study supports HuR's role as an upstream regulator of p62 expression in ARPE-19 cells, helps to understand better the early events in response to a proautophagy stimulus, and suggests that modulation of the autophagy-regulating kinases as potential therapeutic targets for AMD may be relevant. 29576851 2018
CUI: C0242383
Disease: Age related macular degeneration
Age related macular degeneration 		0.020 AlteredExpression disease BEFREE Autophagic flux was also reduced in AMD RPE as compared with normal RPE, as shown by inability of AMD RPE to downregulate p62 levels during starvation. 28055007 2017