|
Liver carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Computational Discovery of Niclosamide Ethanolamine, a Repurposed Drug Candidate That Reduces Growth of Hepatocellular Carcinoma Cells In Vitro and in Mice by Inhibiting Cell Division Cycle 37 Signaling.
|
28284560 |
2017 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Detrusor and sphincter dyssynergia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
To investigate the effect of replication-defective herpes simplex virus (HSV) vectors encoding the kynurenine aminotransferase II (HSVrd-KATII) gene on detrusor-sphincter dyssynergia (DSD) in spinal cord injury (SCI) rats.
|
27995942 |
2017 |
|
Detrusor and sphincter dyssynergia
|
0.020 |
Biomarker
|
disease |
BEFREE |
KAT II gene therapy effectively reduced the urethral pressure, improving detrusor-sphincter dyssynergia (DSD), and detrusor overactivity (DO), probably by blocking the N-methyl-D-aspartate receptor (NMDAr) in the L6-S1 spinal .
|
27391207 |
2017 |
|
Sex Differentiation Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
KAT II gene therapy effectively reduced the urethral pressure, improving detrusor-sphincter dyssynergia (DSD), and detrusor overactivity (DO), probably by blocking the N-methyl-D-aspartate receptor (NMDAr) in the L6-S1 spinal .
|
27391207 |
2017 |
|
Sex Differentiation Disorders
|
0.020 |
GeneticVariation
|
group |
BEFREE |
To investigate the effect of replication-defective herpes simplex virus (HSV) vectors encoding the kynurenine aminotransferase II (HSVrd-KATII) gene on detrusor-sphincter dyssynergia (DSD) in spinal cord injury (SCI) rats.
|
27995942 |
2017 |
|
Ulcerative Colitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of KAT2 mRNA was enhanced in patients with UC and in patients with CD in remission.
|
31666808 |
2019 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of KAT2 mRNA was enhanced in patients with UC and in patients with CD in remission.
|
31666808 |
2019 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, KAT2 could be exploited as a therapeutic target for the management of schizophrenia.
|
31308447 |
2019 |
|
Memory impairment
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Acute administration of BFF816, a systemically active inhibitor of kynurenine aminotransferase II (KAT II), the major KYNA-synthesizing enzyme in the brain, normalized neurochemistry and prevented contextual memory deficits in adult EKyn animals.
|
30311334 |
2019 |
|
Mental Depression
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development.
|
29777939 |
2018 |
|
Depressive disorder
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development.
|
29777939 |
2018 |
|
Depressed mood
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
In this work, we assessed the relationship between single-nucleotide polymorphisms (SNPs) of KAT1, KAT2 and IDO1 gene encoding, and the risk of depression development.
|
29777939 |
2018 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The novel de novo splice alteration c.664 + 2T > G in the DEAF1 gene and the novel de novo missense mutation c.95 C > T in the AADAT gene associated with ASD may be important clues for exploring the etiology of this disorder.
|
29366832 |
2018 |
|
Herpes Simplex Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
To investigate the effect of replication-defective herpes simplex virus (HSV) vectors encoding the kynurenine aminotransferase II (HSVrd-KATII) gene on detrusor-sphincter dyssynergia (DSD) in spinal cord injury (SCI) rats.
|
27995942 |
2017 |
|
Mental disorders
|
0.010 |
Biomarker
|
group |
BEFREE |
Reducing KYNA production through inhibiting kynurenine aminotransferase 2 (KAT2) would be a promising approach to understanding and treating the related neurological and mental disorders.
|
26773745 |
2016 |
|
HIV Infections
|
0.010 |
GeneticVariation
|
group |
BEFREE |
The relationships between polymorphisms in KMO and KATII, psychopathological symptoms, and cerebrospinal fluid (CSF) [KYNA] were evaluated in subjects with and without HIV-infection.
|
27072370 |
2016 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We transfected A-431 tumour cells with the far red-emitting protein Katushka (Kat2), resulting in strong fluorescence allowing for the monitoring of tumour growth when implanted in BALB/c nu/nu mice with a CRi Maestro in vivo imager.
|
22350071 |
2012 |
|
Meningitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of kynurenine aminotransferase II gene C401T polymorphism with immune response in patients with meningitis.
|
21473761 |
2011 |
|
Meningitis, Bacterial
|
0.010 |
GeneticVariation
|
group |
BEFREE |
A significant decrease (p < 0.05) in TNF-α, IL-1β, IL-6, MIP-1αCCL3 and MIP-1β/CCL4 levels was observed in BM patients homozygous (TT) to the SNP AADAT+401C/T.
|
21473761 |
2011 |
|
Huntington Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Genomic organization and expression analysis of mouse kynurenine aminotransferase II, a possible factor in the pathophysiology of Huntington's disease.
|
10441733 |
1999 |