CLDN18, claudin 18, 51208

N. diseases: 52; N. variants: 0
Disease: Gastritis, Atrophic ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0017154
Disease: Gastritis, Atrophic
Gastritis, Atrophic 		0.010 AlteredExpression disease BEFREE These findings provide evidence that claudin-18 normally forms a paracellular barrier against H(+) in the stomach and that its deficiency causes paracellular H(+) leak, a persistent up-regulation of proinflammatory cytokines, chronic recruitment of neutrophils, and the subsequent development of SPEM in atrophic gastritis. 22079592 2012