|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Recent reports show that Golgi membrane protein 1 (GOLM1) is highly expressed in a variety of tumor cells, functions as a negative regulator of T cells and then promotes tumor progression.
|
29637008 |
2018 |
|
Leukocyte adhesion deficiency type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Knockdown of GOLM1 repressed the LAD cell proliferation.
|
29710483 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinically, NSCLC patients with high expression of GOLM1 had shorter overall survival (OS) and high GOLM1 expression in tumor samples was significantly related to malignant phenotype, such as lymph node metastasis and high tumor stage.
|
29637008 |
2018 |
|
Carcinoma of bladder
|
0.010 |
Biomarker
|
disease |
BEFREE |
These results suggest that GP73 promotes bladder cancer invasion and metastasis by inducing the EMT through down-regulating WT1 levels and activating the TGF-β1/Smad2 signalling pathway.
|
29349903 |
2018 |
|
Non-small cell carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of golgi membrane protein 1 promotes non-small-cell carcinoma aggressiveness by regulating the matrix metallopeptidase 13.
|
29637008 |
2018 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present study aimed to investigate the expression of GOLPH2 in pancreatic ductal adenocarcinoma (PDAC) tissues and examined the effects of GOLPH2 on the growth and migration of pancreatic cancer cells.
|
29344673 |
2018 |
|
Compensated cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Receiver operating characteristic curve analysis demonstrated that serum GP73 had a good diagnostic potential for compensated cirrhosis regardless of etiology.
|
29256057 |
2018 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The growth and motility of the PDAC cells was enhanced following overexpression of GOLPH2, whereas downregulating the expression of GOLPH2 impaired the growth, motility and tumorigenesis.
|
29344673 |
2018 |
|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with these functional findings, GP73 blockage could alleviate tunicamycin-induced liver steatosis by reducing SREBPs activation.
|
29097707 |
2017 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We further demonstrated that activation of AKT is the driving force of GOLM1-promoted glioma progression.
|
29282077 |
2017 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Besides, this study provides a novel insight into the mechanism of hepatocarcinogenesis and a promising blueprint for miR-493-5p-GP73 axis-oriented treatment of HCC.
|
28419971 |
2017 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Consistent with these functional findings, GP73 blockage could alleviate tunicamycin-induced liver steatosis by reducing SREBPs activation.
|
29097707 |
2017 |
|
Acute-On-Chronic Liver Failure
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Further ELISA analysis confirmed the significant up-regulation of GP73, MMR, OPN and down-regulation of ATIII, HPX, APO-CII in HBV-ACLF plasma samples (<i>p</i> < 0.01).
|
29270132 |
2017 |
|
Candidemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among them, a cytokine QTL at the NAA35-GOLM1 locus markedly modulated interleukin (IL)-6 production in response to multiple pathogens and was associated with susceptibility to candidemia.
|
27376574 |
2016 |
|
Barrett Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the structure of the Golgi is fragmented and the intracellular localisation of GOLPH2 is altered in BO and oesophageal adenocarcinoma tissue.
|
26461057 |
2015 |
|
Esophageal Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Cellular functions for GOLPH2 are currently unknown, therefore in this study we sought to investigate functional roles for this Golgi-associated protein in oesophageal disease.
|
26461057 |
2015 |
|
Complete atrioventricular block
|
0.010 |
Biomarker
|
disease |
BEFREE |
In conclusion, serum GP73 was found to be correlated with liver pathological grading and staging in patients with CHB, and may be an effective indicator for the evaluation of disease progression.
|
25524053 |
2015 |
|
Adenocarcinoma Of Esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrate that the structure of the Golgi is fragmented and the intracellular localisation of GOLPH2 is altered in BO and oesophageal adenocarcinoma tissue.
|
26461057 |
2015 |
|
Malignant neoplasm of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
GOLPH2 is secreted by oesophageal cancer cells and GOLPH2 expression, cleavage and secretion facilitate cell migration and invasion.
|
26461057 |
2015 |
|
Locally Advanced Malignant Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Six genes were differentially expressed in patients with localized and locally advanced cancer (GOLM1, GBX2, XPO6, SSTR1, TOP2A and cell division cycle associated 5, CDCA5) and three genes (HOXC6, Cyclin-dependent kinase inhibitor 2A (CDKN2A) and MYC binding protein 2, E3 ubiquitin protein ligase, MYCBP2) in patients with a low vs. high Gleason grade/sum.
|
26408707 |
2015 |
|
Childhood Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer.
|
25170213 |
2014 |
|
Adult Hepatocellular Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Effect of GP73 silencing on proliferation and apoptosis in hepatocellular cancer.
|
25170213 |
2014 |
|
Pseudohyperkalemia Cardiff
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TGF-β1 and GP73 expression means were also higher in HCC patients than controls and CHC patients (P < 0.05).
|
24186850 |
2013 |
|
Hepatoblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The interleukin-6 (IL-6) family cytokines were tested for effects on GP73 mRNA and/or protein levels in human hepatoblastoma HepG2 cells.
|
23144154 |
2012 |
|
Liver neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In the present study, we investigated the effect of Fut8 overexpression on GP73 production in the human hepatoma cell line Hep3B.
|
21503570 |
2011 |