TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Disease: Squamous cell carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 GeneticVariation disease BEFREE We experienced a case of eruptive squamous cell carcinoma (SCC) in a patient treated concomitantly with pembrolizumab and imiquimod, a TLR7 agonist. 31599020 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE Differences of tumor-recruiting myeloid cells in murine squamous cell carcinoma influence the efficacy of immunotherapy combined with a TLR7 agonist and PD-L1 blockade. 30926058 2019
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE Whereas the overall expression of TLR7 did not differ between BCC and SCC (30.4% vs. 45.8%, respectively), we found that within the group of SCC, the well-differentiated SCC showed strong tumoral and/or peritumoral immunocellular TLR7 reactivity in contrast to the poorly differentiated SCC (73.33% vs. 11.1%, respectively). 28857981 2017
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.040 Biomarker disease BEFREE TLR7 agonists neutralized both of these strategies, supporting their use in SCCs and other tumors with similar immune defects. 18794336 2008