TLR7, toll like receptor 7, 51284

N. diseases: 276; N. variants: 13
Disease: Lupus Nephritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 AlteredExpression disease BEFREE Specifically, combination therapy inhibited TLR7 expression in the kidneys of mice with lupus nephritis; combination of tacrolimus and mycophenolate mofetil led to better stabilization of the podocyte actin cytoskeleton through the reciprocal regulation of RhoA and Rac1 activities. 29102373 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 Biomarker disease BEFREE In this study, we examined the requirement for type I IFNs in TLR7-stimulated lupus nephritis. 29884703 2018
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 GeneticVariation disease BEFREE In addition, a stratification analysis was performed to investigate the association of TLR7 gene copy number (CN) with lupus nephritis. 20525845 2010
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 AlteredExpression disease BEFREE Our results uncovered an additional pathogenic role of TLR7 and TLR9 in murine lupus nephritis by promoting the expression of nephritogenic gp70 autoantigen. 20619604 2010
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.050 Biomarker disease BEFREE Remarkably, TLR7 and 9 appear to have mutually opposing, pathogenic or protective, impacts on lupus nephritis in MRL/lpr mice. 19451267 2009