TLR8, toll like receptor 8, 51311

N. diseases: 122; N. variants: 8
Disease: Tuberculosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE The A-allele of TLR8 rs3764880 SNP was protective against the development of TB in males (A vs G, OR = 0.58, 95%CI = 0.37-0.91). 30424735 2018
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE In conclusion, these findings provide evidence that TLR7 and TLR8 genetic polymorphisms are associated with susceptibility to MTB infection, and the link is shaped by less effective MTB phagocytosis and impaired TLR signaling. 27156628 2016
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE Association of toll-like receptors with susceptibility to tuberculosis suggests sex-specific effects of TLR8 polymorphisms. 26160538 2015
CUI: C0041296
Disease: Tuberculosis
Tuberculosis 		0.040 GeneticVariation disease BEFREE We found that four polymorphisms in the TLR8 gene on chromosome X showed evidence of association with TB susceptibility in males, including a non-synonymous polymorphism rs3764880 (Met1Val; P = 0.007, odds ratio (OR) = 1.8, 95% c.i.= 1.2-2.7). 18927625 2008