|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here, it is reported that EGFRvIII activates Stat5 and GBM invasion by inducing the expression of a previously established mediator of glioma cell invasion and survival: fibroblast growth factor-inducible 14 (Fn14).
|
29724813 |
2018 |
|
Glioma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results support a role for Fn14 in the more aggressive and invasive phenotype associated with IDH1 WT tumors and indicate that the low levels of Fn14 gene expression noted in IDH1 R132H mutant gliomas may be due to epigenetic regulation via changes in DNA methylation.
|
29453678 |
2018 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor (TNF) superfamily, can stimulate glioma cell invasion and survival via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the transcription factor NF-κB.
|
28103571 |
2017 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Previous observations indicated that SGEF (ARHGEF26), a RhoG-specific guanine nucleotide exchange factor (GEF), is overexpressed in GB tumors and plays a role in promoting TWEAK-Fn14-mediated glioma invasion.
|
26764186 |
2016 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Fn14 engagement as well as Fn14 overexpression can stimulate glioma cell migration, invasion and resistance to chemotherapeutic agents in vitro.
|
26300004 |
2016 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell invasion via binding to fibroblast growth factor-inducible 14 (Fn14) and subsequent activation of the Rho guanosine triphosphatase family member Rac1.
|
23975833 |
2014 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
BAFF, APRIL, TWEAK, BCMA, TACI and Fn14 proteins are related to human glioma tumor grade: immunohistochemistry and public microarray data meta-analysis.
|
24376672 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we report that Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF), a RhoG-specific guanine nucleotide exchange factor, is overexpressed in GB tumors and promotes TWEAK-Fn14-mediated glioma invasion.
|
23775076 |
2013 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Depletion of Ect2 abrogates both TWEAK-induced Cdc42 and Rac1 activation, as well as subsequent TWEAK-Fn14-directed glioma cell migration and invasion.
|
22571869 |
2012 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have previously shown that tumor necrosis factor-like weak inducer of apoptosis (TWEAK), a member of the tumor necrosis factor superfamily, can stimulate glioma cell survival via binding to the Fn14 receptor, activation of the NF-kappaB pathway, and upregulation of BCL-X(L) gene expression.
|
19861406 |
2009 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, Fn14 gene expression levels increase with glioma grade and inversely correlate with patient survival.
|
17018610 |
2006 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Furthermore, Fn14 gene expression levels increase with glioma grade and inversely correlate with patient survival.
|
17018610 |
2006 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We recently showed that fibroblast growth factor-inducible 14 (Fn14) is overexpressed in migrating glioma cells in vitro and in glioblastoma multiforme clinical specimens in vivo.
|
15611130 |
2005 |
|
Glioma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest a positive role for TWEAK and Fn14 in glioma progression and indicate that Fn14 gene expression may serve as a marker for invasive glioma cells.
|
12651623 |
2003 |
|
Glioma
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
These results suggest a positive role for TWEAK and Fn14 in glioma progression and indicate that Fn14 gene expression may serve as a marker for invasive glioma cells.
|
12651623 |
2003 |