|
Leukemia, Myelocytic, Acute
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
The specific association of ZBTB7A mutations with t(8;21) rearranged AML points towards leukaemogenic cooperativity between mutant ZBTB7A and the RUNX1/RUNX1T1 fusion.
|
27252013 |
2016 |
|
Leukemia, Myelocytic, Acute
|
0.320 |
GeneticVariation
|
disease |
BEFREE |
We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21).
|
30251205 |
2019 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival.
|
29207095 |
2018 |
|
Malignant Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
|
26455326 |
2016 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Red Blood Cell Count measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Mean Corpuscular Volume (result)
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Finding of Mean Corpuscular Hemoglobin
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease.
|
27863252 |
2016 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry.
|
30239722 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our study uncovers the loss-of-function mutation in ZBTB7A as a novel mechanism causing elevated glycolysis in human cancer, which carries important therapeutic implication.
|
26455326 |
2016 |
|
Primary malignant neoplasm
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mining The Cancer Genome Atlas gastric adenocarcinoma dataset identified a frequent loss of the zinc finger and BTB domain containing 7A (ZBTB7A) gene locus and a significant correlation between low ZBTB7A expression and poor patient survival.
|
29207095 |
2018 |
|
Chronic Lymphocytic Leukemia
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
ATM mutation rather than BIRC3 deletion and/or mutation predicts reduced survival in 11q-deleted chronic lymphocytic leukemia: data from the UK LRF CLL4 trial.
|
24584352 |
2014 |
|
leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We analyzed 529 CLL samples from the LRF CLL4 (Leukaemia Research Foundation Chronic Lymphocytic Leukemia 4) trial (chlorambucil v fludarabine with or without cyclophosphamide) at the time of random assignment for mutations in the TP53 gene.
|
21483000 |
2011 |
|
Tumor Progression
|
0.020 |
GeneticVariation
|
phenotype |
BEFREE |
Somatic human ZBTB7A zinc finger mutations promote cancer progression.
|
26455326 |
2016 |
|
Hormone refractory prostate cancer
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Conversely, this response is bypassed with deletion of either Trp53 or Zbtb7a together with Pten, leading to the development of castration-resistant prostate cancer (CRPC).
|
23727860 |
2013 |
|
Malignant tumor of cervix
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we used an RNAi strategy to silence the Pokemon gene in a cervical cancer model.
|
20879980 |
2010 |
|
Hemoglobin F Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
First, transcription factors, BCL11A and LRF/ZBTB7A, that mediate silencing of the β-like fetal (γ-) globin gene after birth have been identified and demonstrated to act at the γ-globin promoters, precisely at recognition sequences disrupted in rare individuals with hereditary persistence of fetal hemoglobin.
|
30355263 |
2019 |
|
Acute monocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21).
|
30251205 |
2019 |
|
Sleep Apnea Syndromes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a de novo likely pathogenic heterozygous missense variant of ZBTB7A (NM_015898.3:c.1152C>G, p.(Cys384Trp)) in a Japanese boy with macrocephaly, intellectual disability, and sleep apnea.
|
31645653 |
2020 |
|
Macrocephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a de novo likely pathogenic heterozygous missense variant of ZBTB7A (NM_015898.3:c.1152C>G, p.(Cys384Trp)) in a Japanese boy with macrocephaly, intellectual disability, and sleep apnea.
|
31645653 |
2020 |
|
Hereditary persistence of fetal hemoglobin thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings clarify how these HPFH-associated mutations operate and demonstrate that BCL11A and ZBTB7A are major direct repressors of the fetal globin gene.
|
29610478 |
2018 |
|
Cervix carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we used an RNAi strategy to silence the Pokemon gene in a cervical cancer model.
|
20879980 |
2010 |
|
cervical cancer
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, we used an RNAi strategy to silence the Pokemon gene in a cervical cancer model.
|
20879980 |
2010 |