|
Sleep Apnea Syndromes
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a de novo likely pathogenic heterozygous missense variant of ZBTB7A (NM_015898.3:c.1152C>G, p.(Cys384Trp)) in a Japanese boy with macrocephaly, intellectual disability, and sleep apnea.
|
31645653 |
2020 |
|
Macrocephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified a de novo likely pathogenic heterozygous missense variant of ZBTB7A (NM_015898.3:c.1152C>G, p.(Cys384Trp)) in a Japanese boy with macrocephaly, intellectual disability, and sleep apnea.
|
31645653 |
2020 |
|
Rectal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Prognostic value of nuclear FBI-1 in patients with rectal cancer with or without preoperative radiotherapy.
|
31612040 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
An animal study further confirmed the role of ZBTB7 in the growth of renal carcinoma.
|
29673422 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
Small (Hedge's g=0.19) and highly variable effects of LRF rTMS over right DLPFC in TBI depression were observed.
|
31018810 |
2019 |
|
Depressive disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Small (Hedge's g=0.19) and highly variable effects of LRF rTMS over right DLPFC in TBI depression were observed.
|
31018810 |
2019 |
|
Hemoglobin F Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
First, transcription factors, BCL11A and LRF/ZBTB7A, that mediate silencing of the β-like fetal (γ-) globin gene after birth have been identified and demonstrated to act at the γ-globin promoters, precisely at recognition sequences disrupted in rare individuals with hereditary persistence of fetal hemoglobin.
|
30355263 |
2019 |
|
Acute monocytic leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We identified ASXL2 (34.1%) and ZBTB7A (9.8%) mutations in only AML patients with t(8;21).
|
30251205 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Small (Hedge's g=0.19) and highly variable effects of LRF rTMS over right DLPFC in TBI depression were observed.
|
31018810 |
2019 |
|
Mesenchymal Cell Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here we characterize a new circRNA (circPOK) encoded by the Zbtb7a gene (also kown as POKEMON, LRF) in the context of mesenchymal tumor progression. circPOK functions as a non-coding proto-oncogenic RNA independently and antithetically to its linear transcript counterpart, which acts as a tumor suppressor by encoding the Pokemon transcription factor.
|
31209250 |
2019 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
An animal study further confirmed the role of ZBTB7 in the growth of renal carcinoma.
|
29673422 |
2019 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Meanwhile, the high expression of ZBTB7A may promote cell migration, invasion and tumour metastasis, which may be related to EMT events by regulating NF-κB.
|
31385585 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings highlight the importance of HP1γ and its reader activity in lung adenocarcinoma tumorigenesis and reveal a unique lung adenocarcinoma-promoting mechanism in which HP1γ downregulates NCOR2 and ZBTB7A to enhance expression of protumorigenic genes.<b>Significance:</b> Direct epigenetic repression of the transcription-repressive regulators NCOR2 and ZBTB7A by the histone reader protein HP1γ leads to activation of protumorigenic genes in lung adenocarcinoma.<i></i>.
|
29764865 |
2018 |
|
Fibrosis, Liver
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
We found high levels of Osteopontin and Pokémon gene expression in group I. Osteopontin levels were higher also in patients with liver fibrosis was correlated to high levels of parameters such as alpha fetoprotein and caspase.
|
30417409 |
2018 |
|
Hereditary persistence of fetal hemoglobin thalassemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
These findings clarify how these HPFH-associated mutations operate and demonstrate that BCL11A and ZBTB7A are major direct repressors of the fetal globin gene.
|
29610478 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.010 |
Biomarker
|
disease |
BEFREE |
ZBTB7 evokes 5-fluorouracil resistance in colorectal cancer through the NF‑κB signaling pathway.
|
30106136 |
2018 |
|
Malignant neoplasm of urinary bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the association between ZBTB7 expression in bladder cancer tissues and the prognosis of patients remains unclear.
|
29085492 |
2017 |
|
Bladder Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the association between ZBTB7 expression in bladder cancer tissues and the prognosis of patients remains unclear.
|
29085492 |
2017 |
|
Carcinoma, Transitional Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The aim of the current study was to detect the expression of ZBTB7 in transitional cell carcinoma (TCC) of the bladder and normal bladder mucous tissues to evaluate the diagnostic and prognostic value of ZBTB7 in TCC of the bladder.
|
29085492 |
2017 |
|
Cholangiocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
miR-106b regulates the 5-fluorouracil resistance by targeting Zbtb7a in cholangiocarcinoma.
|
28881782 |
2017 |
|
Congenital contractural arachnodactyly
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that miR-106b can reverse 5-FU resistance via Zbtb7a suppression, thus offer a novel and powerful strategy for CCA chemotherapy.
|
28881782 |
2017 |
|
Transitional cell carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression and clinical significance of ZBTB7 in transitional cell carcinoma of the bladder.
|
29085492 |
2017 |
|
Carcinoma of bladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
However, the association between ZBTB7 expression in bladder cancer tissues and the prognosis of patients remains unclear.
|
29085492 |
2017 |
|
TARSAL-CARPAL COALITION SYNDROME
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of ZBTB7 mRNA and protein in TCC tissue was detected and TCC expression was significantly higher in TCC tissue than in normal bladder mucous tissues (P<0.05).
|
29085492 |
2017 |
|
Choriocarcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
FBI-1 Is Overexpressed in Gestational Trophoblastic Disease and Promotes Tumor Growth and Cell Aggressiveness of Choriocarcinoma via PI3K/Akt Signaling.
|
26093985 |
2015 |