|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The lncRNA Wilms tumor 1 Antisense RNA (WT1-AS) is a potential tumor suppressor in some types of cancers.
|
30720155 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The lncRNA WT1 antisense RNA (WT1-AS) serves as a tumor suppressor in various cancers.
|
30666161 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
To demonstrate proof of concept, we showed that perturbations targeting OIP5-AS1 (an inferred tumor suppressor) and TUG1 and WT1-AS (inferred onco-lncRNAs) dysregulated cancer genes and altered proliferation of breast and gynecologic cancer cells.
|
29617668 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, ectopic expression of WT1-AS was demonstrated to inhibit tumor growth and metastasis in vivo.
|
26449525 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
WT1-AS expression correlated negatively with WT1 expression in HCC tumor tissue.
|
26462627 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The identification of WT1 as a prognostic marker confirms its role in high-grade uterine sarcoma and carcinosarcoma tumor biology.
|
21734473 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These investigations confirmed a liver tumor suppressor locus at human 11p11.2, identified Wt1 as a potential effector of 11p11.2-mediated tumor suppression, and subsequently identified human SYT13 as a strong candidate for the 11p11.2 liver tumor suppressor gene.
|
20840848 |
2010 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The initial discovery of WT1 as the causative gene in an autosomal-recessive condition identified it as a tumor suppressor gene whose mutations are associated with urogenital disease and the development of kidney tumors.
|
17361230 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
During the last few years, a wealth of experiments has been carried out to address the function of WT1 as a tumor suppressor and developmental regulator.
|
9607183 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We conclude that induction of p21 expression may contribute to WT1-dependent differentiation pathways in the kidney and potentially to the function of WT1 as a tumor suppressor gene.
|
9108440 |
1997 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Thus, 15 of the 41 Wilms tumors (37%) had WT1 and WIT1 deletions or LOH on 11p, and only 2 of the 27 tumors whose nonneoplastic normal tissues were available for study showed LOH limited to the 11p15 region.
|
8393432 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Extrarenal Wilms' tumors. A study of their relationship with classical renal Wilms' tumor using expression of WT1 as a molecular marker.
|
8388523 |
1993 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The ratio of WT1:WIT1 expression remained relatively constant in homotypic tumors but deviated significantly in heterotypic tumors.
|
1335280 |
1992 |