|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study investigated antioxidant and oxidative stress markers, sexual hormones levels, mRNA levels of vascular endothelial growth factor (Vegfa), synaptonemal complex protein (Sycp3), Wilms tumor gene (Wt1) as well as histopathological and immunohistochemical examination.
|
30530043 |
2019 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Predefined and pre-weighted objective criteria and essential role of Wilms׳ tumor wild type gene (WT1) for maintaining transformed features of cancer cells confirm the high potency of WT1 as a valuable cancer antigen.
|
25936349 |
2015 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Classification of a frameshift/extended and a stop mutation in WT1 as gain-of-function mutations that activate cell cycle genes and promote Wilms tumour cell proliferation.
|
24619359 |
2014 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Collectively, our studies identify WT1 as a novel Hsp90 client and support the crucial role for the WT1-Hsp90 interaction in maintaining leukemia cell survival.
|
20651072 |
2010 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our previous results have identified imprinted transcripts (WT1-AS and AWT1) from the WT1 locus at 11p13 and showed LOI of these in some WTs.
|
18644976 |
2008 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In the current study quantitative reverse transcription-polymerase chain reaction and immunostaining were used simultaneously to examine the relationship between WT1 RNA and protein level and also to evaluate WT1 as a tool to differentiate aplastic anemia (AA) and MDS refractory anemia (RA).
|
17803653 |
2007 |
|
Nephroblastoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
We demonstrate that the expression of WT1-AS correlates with methylation of the antisense regulatory region (ARR) in WT1 intron 1, displaying imprinted monoallelic expression in normal kidney and loss of imprinting in WT.
|
17940140 |
2007 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The authors hypothesized that Wilms tumor suppressor 1 gene (WT1) sense and antisense (WT1-AS) expression and their promoter methylation status could characterize ovarian clear cell adenocarcinoma from ovarian serous adenocarcinoma.
|
16134181 |
2005 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that SNPs in WT1 and WIT1 genes are significantly associated with FSGS, suggesting that variants in these genes may mediate pathogenesis by altering WT1 function.
|
15687485 |
2005 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After allogeneic stem cell transplantation (SCT), we evaluated the use of the Wilms' tumor gene (WT1) as a minimal residual disease (MRD) marker in 32 patients (28 chronic myeloid leukemia, three acute lymphoblastic leukemia and one acute myeloid leukemia).
|
14704656 |
2004 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, WTs display hypomethylation and biallelic expression of WT1-AS.
|
10811108 |
2000 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Wilms tumor gene (WT1) as a new marker for the detection of minimal residual disease in leukemia.
|
9669676 |
1998 |
|
Nephroblastoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Two Wilms tumor-aniridia-genitourinary abnormalities-mental retardation syndrome patients had total hemizygous WT1 and WIT1 deletions in both constitutional and nonsporadic type tumor cells.
|
8393432 |
1993 |
|
Nephroblastoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Extrarenal Wilms' tumors. A study of their relationship with classical renal Wilms' tumor using expression of WT1 as a molecular marker.
|
8388523 |
1993 |
|
Nephroblastoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that expression patterns of the WT1 and WIT1 genes can be closely correlated to Wilms' tumor histopathology.
|
1335280 |
1992 |