PDE4A, phosphodiesterase 4A, 5141

N. diseases: 168; N. variants: 3
Disease: Dermatologic disorders ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.030 Biomarker group BEFREE Though PDE4 inhibitors have been approved for pulmonary and dermatological diseases, the role of PDE4 inhibition in modulating mucosal immunity in the intestine remains ill-defined. 30883697 2019
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.030 AlteredExpression group BEFREE Both phosphodiesterase (PDE4) inhibitors and omega-9 fatty acids such as oleic acid (OA) show anti-inflammatory activity for treating inflamed skin diseases. 30951898 2019
CUI: C0037274
Disease: Dermatologic disorders
Dermatologic disorders 		0.030 Biomarker group BEFREE One isoform, PDE4, is overactive in chronic relapsing inflammatory skin diseases: psoriasis and eczema/atopic dermatitis, and in several cancers. 29593534 2018