|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between phosphodiesterase 4D polymorphism SNP83 and ischemic stroke.
|
24365247 |
2014 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
the SNPs of the PDE4D (83T/C) and IL-1 (-889C/T) were associated with increased risk for the development of IS in Northern Han Chinese.
|
19786079 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A recent meta-analysis reported that no genetic variant of PDE4D demonstrated a reproducible association with ischemic stroke, especially when analyzed with respect to white subjects exclusively.
|
20182758 |
2010 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PDE4D gene is not a major risk factor for ischemic stroke, or early atherosclerosis, within the 2 European population samples studied.
|
15802632 |
2005 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Multivariable adjusted analysis demonstrated a statistically significant relationship between SNP 83 of PDE4D gene polymorphism and increasing odds of IS under the dominant model of inheritance (OR, 1.59; 95% CI, 1.02 to 2.50; p value = 0.04) after adjustment of potential confounding variables.
|
28562233 |
2017 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
The PDE4D gene is not a major risk factor for noncardiogenic ischemic stroke in a Korean population, which supports the recent evidence suggesting that the causative genetic variants of ischemic stroke may differ across populations.
|
19399275 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Investigation of single nucleotide polymorphisms in phosphodiesterase 4D gene in Mongol and Han patients with ischemic stroke in Inner Mongolia.
|
26345966 |
2015 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
PDE4D gene in the STRK1 region on 5q12: susceptibility gene for ischemic stroke.
|
18220751 |
2007 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accumulating evidences have shown that inhibition of PDE4 is beneficial for the functional recovery after cerebral ischemia; i. subtype D of PDE4 (PDE4D) is viewed as a risk factor for ischemic stroke; ii. inhibition of PDE4 enhances neurological behaviors, such as learning and memory, after stroke in rodents; iii.PDE4 inhibition increases dendritic density, synaptic plasticity and neurogenesis; iv. activation of cAMP/CREB signaling by PDE4 inhibition causes an endogenous increase of BDNF, which is a potent modulator of neuroplasticity; v. PDE4 inhibition is believed to restrict neuroinflammation during ischemic stroke.
|
30416389 |
2018 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Studies that employ genome-wide linkage scans with hundreds of small nuclear families have identified new susceptibility genes for coronary artery disease and myocardiaI infarction, including ALOX5AP (encoding 5-lipoxygenase-activating protein) associated with myocardial infarction and stroke and PDE4D (encoding phosphodiesterase 4D) for ischemic stroke.
|
15861005 |
2005 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Phosphodiesterase 4D (PDE4D) gene variants and the risk of ischemic stroke in a South Indian population.
|
19608201 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Familial aggregation, the PDE4D gene, and ischemic stroke in a genetically isolated population.
|
16162858 |
2005 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our present findings show that polymorphisms in the PDE4D gene are associated with an increased risk of ischaemic stroke in the Chinese Han population.
|
19196240 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis revealed a significant association of PDE4D gene variants with the risk of ischemic stroke, and further investigations are warranted to evaluate possible ethnic-specific effects.
|
21677445 |
2011 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that common variants in PDE4D may contribute to the genetic risk for ischemic stroke in multiple populations.
|
16130105 |
2005 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No association of the variants in PDE4D with IS was observed in our study.
|
20357438 |
2010 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These studies demonstrated levels of serum androgens, C-reactive protein, and advanced glycation endproducts; thrombin generation; left ventricular mass; depressive symptoms; phosphodiesterase 4D single nucleotide polymorphisms; coagulation factor XII gene; peak thrombus generation; and lower cognitive functioning were independent risk factors for ischemic stroke in older adults.
|
31127075 |
2019 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the association between the PDE4D gene polymorphisms and young-onset IS in Chinese population.
|
23466835 |
2016 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association between PDE4D gene and ischemic stroke: recent advancements.
|
26004910 |
2016 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the univariate analysis, the rs918592 polymorphism in PDE4D was found to be significantly associated with ischemic stroke with the recessive model (P = 0.02), whereas no association with ischemic stroke was observed for rs4075015 and rs4537545 in IL6R.
|
26782593 |
2015 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke.
|
14517540 |
2003 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We tested for genotype and haplotype association of polymorphisms of the PDE4D gene with ischemic stroke in a population-based, biracial, case-control study.
|
16373644 |
2006 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Aim Undertake a multivariate analysis of six single nucleotide polymorphisms within the phosphodiesterase 4D gene in a previously defined Australian stroke cohort, to determine whether these single nucleotide polymorphisms have an association with ischemic stroke.
|
21989204 |
2011 |
|
Ischemic stroke
|
0.100 |
Biomarker
|
disease |
BEFREE |
We present results from application of our approach to data on a possible association between PDE4D and ischemic stroke.
|
19409523 |
2009 |
|
Ischemic stroke
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We assessed possible associations between ischaemic stroke and nine preselected SNPs in the chromosome regions of the PDE4D gene, including rs12188950 (SNP45) and rs3887175 (SNP39); the ALOX5AP gene, including rs17222814 (SG13S25) and the promoter region of the MHC class II transactivator, MHC2TA.
|
18398440 |
2008 |