PDE4D, phosphodiesterase 4D, 5144

N. diseases: 210; N. variants: 68
Disease: Atherosclerosis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE Integrin α5β1 regulates PP2A complex assembly through PDE4D in atherosclerosis. 31408443 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE Phosphodiesterase 4D (PDE4D), through the regulation of cyclic AMP, modulates inflammation and other processes that affect atherosclerosis and stroke. 23863764 2013
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 GeneticVariation disease BEFREE Phosphodiesterase 4 D gene polymorphism in relation to intracranial and extracranial atherosclerosis in ischemic stroke. 22045424 2011
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease LHGDN The PDE4D SNPs, showed a non-significant risk in the ICVD group which increased for the Large Artery Atherosclerosis subtype (SNP45: RR=1.43, P=0.063, SNP41: RR=1.57, P=0.018). 17655870 2007
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE The PDE4D gene is not a major risk factor for ischemic stroke, or early atherosclerosis, within the 2 European population samples studied. 15802632 2005
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.060 Biomarker disease BEFREE We propose that PDE4D is involved in the pathogenesis of stroke, possibly through atherosclerosis, which is the primary pathological process underlying ischemic stroke. 14517540 2003