|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To further explore the relationship between DCDC2 and dyslexia, a genetic knockout (KO) of the rodent homolog of DCDC2 (Dcdc2) was created.
|
29232042 |
2019 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Twenty two functional variants across six RELN signalling genes (RELN, VLDLR, APOER2, DAB1, LIS1 and NDEL1) and two dyslexia candidate genes (DCDC2 and ROBO1) were analyzed for association in twenty six nuclear and three extended families with individuals affected with dyslexia.
|
30199849 |
2018 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, on the basis of multiple strands of evidence, we conclude that the DCDC2 deletion is not a strong risk factor for dyslexia.
|
28742079 |
2017 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Several candidate genes have been proposed to be implicated in dyslexia susceptibility, such as DYX1C1, ROBO1, KIAA0319, and DCDC2.
|
28074887 |
2017 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Dyslexia is a reading disorder with strong associations with KIAA0319 and DCDC2.
|
28182973 |
2017 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results do not reveal a migration disorder in the mouse model, adding to the body of evidence available for Dcdc2 and Dyx1c1 that, unlike in the rat in utero knockdown models, the dyslexia-susceptibility candidate mouse homolog genes do not play an evident role in neuronal migration.
|
27510895 |
2017 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We previously reported that two risk haplotypes, each in strong linkage disequilibrium (LD) with an allele of READ1, a polymorphic compound short tandem repeat within intron 2 of risk gene DCDC2, are associated with RD and LI.
|
26660103 |
2016 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study provides support for DCDC2 as a risk gene for reading disability and suggests that this gene is also operative for typical reading development in the Han population.
|
27100778 |
2016 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results corroborate the emerging role of DCGs in ciliary function and characterize functional noncoding elements, X-box promoter motifs, in DCG promoter regions, which thus can be targeted for mutation screening in dyslexia and ciliopathies associated with these genes.-Tammimies, K., Bieder, A., Lauter, G., Sugiaman-Trapman, D., Torchet, R., Hokkanen, M.-E., Burghoorn, J., Castrén, E., Kere, J., Tapia-Páez, I., Swoboda, P. Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor (RF) X transcription factors through X-box promoter motifs.
|
27451412 |
2016 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We measured motion perception in two groups of dyslexics, with and without a deletion within the DCDC2 gene, a risk gene for dyslexia.
|
26019324 |
2015 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Expression patterns of speech disorder- (FoxP2, FoxP1, CNTNAP2, and CMIP) and dyslexia- (ROBO1, DCDC2, and KIAA0319) related genes were analyzed.
|
24769279 |
2014 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
As expected, there were associations with known RD risk genes KIAA0319 and DCDC2.
|
24509779 |
2014 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A deletion in DCDC2/intron 2 (DCDC2d), which encompasses a regulatory region named 'regulatory element associated with dyslexia 1' (READ1), increases the risk for dyslexia.
|
24926531 |
2014 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We previously identified a putative functional risk variant, named BV677278 for its GenBank accession number, for RD in DCDC2.
|
23746548 |
2013 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of genetic variants of dyslexia candidate genes KIAA0319 and DCDC2 in Indian population.
|
23677054 |
2013 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among these, DCDC2 and KIAA0319 have emerged as the strongest candidate genes for dyslexia; however studies have not provided uniformly supportive results.
|
24301907 |
2013 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this review, we summarized the ongoing association studies concerning DCDC2 polymorphisms and dyslexia risk by using meta-analysis and revealed that DCDC2 rs807701 might contribute significantly to dyslexia risk.
|
23229871 |
2013 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we explored the contribution of two DCDC2 markers to dyslexia, related reading and memory phenotypes in nuclear families of Italian origin.
|
21881542 |
2012 |
|
Dyslexia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
These studies suggest that the association of BV677278 with RD reflects a role as a modifier of DCDC2 expression.
|
21042874 |
2011 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This analysis focused on two MMN components, an early MMN (188-300 ms) and a late MMN (300-710 ms), and the dyslexia candidate genes KIAA0319 and DCDC2 on chromosome 6.
|
21104116 |
2011 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We replicate association between KIAA0319 and DCDC2 and dyslexia and provide evidence to support a role for KIAA0319 in oral language ability.
|
21165691 |
2011 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study provides support for DCDC2 as a risk gene for reading disorder, and suggests that this risk factor acts on normally varying reading skill in the general population.
|
20068590 |
2010 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thus, our data further corroborate association of DCDC2 with dyslexia.
|
19238550 |
2009 |
|
Dyslexia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four of the candidate genes (DYX1C1, KIAA0319, DCDC2, and ROBO1) appear to function in neuronal migration and guidance, suggesting the importance of early neurodevelopmental processes in RD.
|
19302769 |
2009 |
|
Dyslexia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
We thus conclude that the causative variant/s in DCDC2 conferring susceptibility to dyslexia in our sample remain/s to be identified.
|
19018237 |
2008 |