|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We documented consistently high PDGF-A expression in primary biopsies and patients' plasma and tracked PDGFRA signaling in primary tumors, achieving evidence of its activation.
|
24480986 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In IGF2-low tumors, other growth factors (FGF9, PDGFA) are more expressed than in IGF2-high tumors, suggesting that they play a compensatory role in tumor progression.
|
25089899 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcription profile analysis of these tumors revealed induction of transcripts known to be associated with myxoid liposarcoma and novel candidate genes, including PDGFA, whose expression was confirmed in human tumor samples.
|
16849546 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of PDGF-A, a potent growth factor for fibroblasts, has been detected in desmoplastic small round cell tumors and has been linked to the characteristic desmoplasia in these tumors.
|
15389255 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Chinese hamster ovary cells overexpressing pro-PDGF-A (ARKA(86)) failed to induce tumors in nude mice.
|
12670890 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Significantly higher expression levels of VEGF, VEGF-B, VEGF-C, basic fibroblast growth factor, Ang-2, transforming growth factor alpha, and PDGF-A (P < 0.0001-0.026) were found in advanced-stage tumors (stages 3 and 4) compared with low-stage tumors (stages 1, 2, and 4S).
|
10815914 |
2000 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Vascular counts in tumors correlated with each expression frequency of VEGF and PDGF-A mRNA.
|
8619189 |
1996 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A number of growth factors, including platelet derived growth factors A and B (PDGF-A and -B), insulin-like growth factor I and transforming growth factor-beta (TGF-beta), and some of their receptors, have been reported to be expressed by MM cells, and each has the potential to play a role as a growth stimulant for MM or to modify immune responses to the tumour.
|
7664867 |
1995 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
PDGF-A mRNA and protein were expressed at a higher level in the tumor explant cell lines, suggesting a correlation of tumorigenicity with A chain production.
|
8427711 |
1993 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In some publications, the presence of PDGF A-chain transcripts with this exon-6-derived sequence was suggested to be tumour specific.
|
1396665 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In certain Wilms tumors, the platelet-derived growth factor A chain (PDGF-A) is overexpressed; it has therefore been suggested that it may play an autocrine role in development of these neoplasms.
|
1332065 |
1992 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The PDGF A-chain was expressed in all of the tumors, with the exception of the malignant ependymoma and in both nontumor glial cell cultures.
|
1997889 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, the tumor cells expressed more mRNA for PDGF A chain than for PDGF B chain and PDGF receptor.
|
2845420 |
1988 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the human tumor system PDGF A- and B-chain transcripts were present at similar levels before and after transplantation in the nude mouse.
|
2842041 |
1988 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Expression of the PDGF A-chain gene is independent of that of the PDGF B-chain in a number of human tumour cell lines, and secretion of a PDGF-like growth factor of relative molecular mass 31,000 correlates with expression of A- but not B-chain messenger RNA.
|
3754619 |
1986 |