SIRT6, sirtuin 6, 51548

N. diseases: 195; N. variants: 2
Disease: Metabolic Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Sirt6 may be a pharmacological target to remedy metabolic diseases. 30530497 2019
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE SIRT6, a nuclear sirtuin, is implicated in the development of metabolic disorders. 29319170 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Because SIRT6 has been implicated in longevity, metabolism, DNA-repair, and inflammatory response reduction, it is an interesting target in inflammatory and metabolic diseases as well as in cancer. 29515203 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 AlteredExpression group BEFREE SIRT6 overexpression improves metabolic diseases, such as hypercholesterolemia, cholesterol-related disease, and type 2 diabetes via AMP-activated protein kinase (AMPK) activation. 30078674 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Therefore, SIRT6 has emerged as a therapeutic target for the treatment of metabolic disorder and age-related diseases. 29233643 2018
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Our results suggest Sirt6 as an attractive therapeutic target for treating obesity and obesity-related metabolic disorders. 28250020 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Recent studies established the critical role of SIRT6 in the pathophysiology of metabolic disease, as well as its roles in longevity and cancer. 29177584 2017
CUI: C0025517
Disease: Metabolic Diseases
Metabolic Diseases 		0.080 Biomarker group BEFREE Through these functions, SIRT6 protects against aging-associated pathologies including metabolic disease and cancer, and can promote longevity in mice. 27836583 2017